The research lab led by Scott G Holmes at Wesleyan University focuses on understanding how specific proteins interact to regulate key processes in cells, particularly those related to gene expression and chromosome stability. By studying histones H1 and H2A.Z, the lab investigates how the balance between these proteins affects how genes are turned on or off and how chromosomes are properly segregated during cell division. This research is important for uncovering the basis of various diseases linked to chromatin dysfunction.