Chaolin Zhang's research lab at Columbia University focuses on understanding how RNA molecules and their binding proteins regulate gene expression, especially in the brain. They study alternative splicing, a process that generates diverse proteins from a single gene, which is crucial for the function of different neuronal cell types. Their work aims to map regulatory elements that control this splicing and investigate how alterations in these processes can lead to neurological disorders and other diseases.

Dr. Liang Tong's lab focuses on understanding how messenger RNAs (mRNAs) are processed and regulated within cells. By studying the proteins involved in mRNA stability and quality control, the lab aims to uncover mechanisms that ensure mRNAs are correctly modified before they are translated into proteins. This research is crucial as defects in mRNA processing can lead to various diseases, including some cancers.

Dr. Jellert Gaublomme's lab at Columbia University focuses on understanding how cells in tumors interact with their environment and how these interactions influence cancer progression and treatment responses. By using innovative CRISPR techniques, the lab aims to map the complex cellular architecture within tumors and identify potential therapeutic targets that can help enhance the immune system's ability to fight cancer. This research is crucial for developing more effective treatments for liver cancer and other malignancies.

Dr. Rafael Yuste's lab at Columbia University investigates the complex workings of the visual cortex, focusing on the role of neuronal ensembles and dendrites in processing visual information. His team uses advanced optical techniques to explore how these ensembles affect visual perception and how dendrites, often overlooked in neuroscience, contribute to neuronal decision-making. Ultimately, this research aims to better understand brain function and develop novel therapies for visual impairments.