Dr. Thomas J. Begley's lab at SUNY Albany focuses on understanding how genetic and environmental factors interact to influence cellular responses to toxic substances, particularly naphthalene found in wood smoke. They explore how modifications to RNA and DNA impact gene expression and responses to cell stress. By using techniques in molecular biology and animal models, the lab aims to uncover novel strategies to reduce the harmful effects of air pollutants on human health.

Dr. Andrew Berglund's lab focuses on developing new small molecule therapeutics to treat neuromuscular and neurodegenerative diseases, particularly myotonic dystrophy and spinocerebellar ataxias. The research aims to understand the mechanisms through which expanded RNA sequences disrupt normal RNA processing and to design drugs that can reduce the toxicity of these expanded RNAs. By utilizing both in vitro and in vivo models, the lab evaluates the efficacy and safety of these compounds, potentially advancing towards future clinical therapies.

Dr. Melinda Larsen's lab focuses on understanding and treating fibrosis, particularly in salivary glands damaged by radiation or diseases like Sjogren's Syndrome. They explore how certain cells contribute to fibrosis and investigate potential therapies that could improve organ regeneration. This research is crucial as fibrosis is a major health issue, contributing to significant morbidity and mortality.

Dr. Annalisa Scimemi's lab studies how specific brain cells, called pyramidal cells, integrate different types of signals in the hippocampus, which is critical for memory and spatial navigation. The lab investigates how a neurotransmitter called glutamate, which is important for communication between neurons, can affect both excitatory and inhibitory signals onto these pyramidal cells. Understanding these mechanisms may help develop new treatments for conditions like epilepsy and autism spectrum disorder.