Dr. Houfu Guo's lab at the University of Kentucky focuses on understanding how certain enzymes modify collagen and contribute to the spread of lung cancer. Specifically, they are investigating the role of a newly identified enzyme, lysyl hydroxylase 2b (LH2b), in promoting cancer metastasis. By studying its structure and function, the lab aims to reveal new therapeutic targets for treating lung cancer and potentially other cancer types as well.

Dr. Ann C. Morris's lab at the University of Kentucky specializes in studying the CHD7 gene, which is critical for proper eye development. By investigating how CHD7 influences retinal cell differentiation, the lab aims to understand the genetic basis of ocular defects like coloboma and the broader implications for congenital disorders such as CHARGE syndrome. Their research combines genetic models, advanced imaging, and transcriptomic analyses.

Dr. Selenica's lab focuses on understanding the role of a specific protein modification in brain diseases like Alzheimers and related dementias. They investigate how this modification affects a protein called TDP-43, which is linked to cognitive decline. The research aims to uncover how changes in TDP-43 contribute to neurological disorders, providing insights that could lead to new therapeutic approaches.

Dr. Ashley Winn Seifert's lab at the University of Kentucky investigates how certain immune cells, called tissue resident macrophages, influence the body's ability to regenerate damaged tissues. By studying spiny mice, which can regenerate their musculoskeletal tissues, the lab aims to understand the differences between regenerative healing and scarring seen in other mice. The goal is to uncover cellular and molecular mechanisms that can be applied to improve healing processes in humans.

Dr. Wang-Xia Wang’s lab at the University of Kentucky focuses on understanding how microRNAs influence neuroinflammation and the role they play in Alzheimer's disease. The lab is particularly interested in a specific microRNA, miR-223, which affects the ApoE pathway, a critical component linked to neuroinflammation and sex-related differences in disease response. Through various experimental techniques, the lab aims to develop new therapeutic strategies that could improve treatment outcomes for Alzheimer's disease, especially in female patients who may be disproportionately affected by these conditions.