The research lab led by Dr. Vera Gorbunova at the University of Rochester focuses on understanding the aging process and strategies to maintain genomic stability in cells. They investigate how certain genes, particularly Sirtuin 6, influence lifespan and epigenetic rejuvenation, and use comparative genomics to explore longevity mechanisms in various animal species. The goal is to apply these insights to prevent age-related diseases such as Alzheimer's.

Dr. Andrei Seluanov's lab at the University of Rochester focuses on understanding how the stability of the epigenome is regulated during aging, particularly through the action of the SIRT6 protein. The lab investigates the molecular mechanisms that underlie age-related declines in cell and organ function, leveraging techniques like mass spectrometry and genetic models to explore how SIRT6 influences DNA repair and longevity. Their work aims to discover new treatments for age-related diseases by revealing insights into the aging process.

Dr. Dragony Fu's lab at the University of Rochester focuses on understanding the critical roles of tRNA modification enzymes in human health. They investigate how alterations in these enzymes can lead to diseases by studying their impact on tRNA structure, function, and the regulation of cellular processes. The lab aims to build new models to study these mechanisms, with the ultimate goal of uncovering therapeutic strategies for diseases linked to tRNA modifications.

Dr. Hengwei Zhang's research lab focuses on understanding how cellular aging affects bone healing, especially in elderly patients who suffer from fractures. His work investigates a specific type of aging-related cell known as detrimental senescent cells that hinder the healing process. By exploring the mechanisms behind these cells, the lab aims to develop novel therapies to improve recovery from bone fractures in older adults.