Professor Joseph M Bollinger's lab at Penn State University studies metalloenzymes, which are specialized proteins that use metal ions to catalyze important chemical reactions, particularly in drug synthesis. The lab focuses on understanding how these enzymes activate strong chemical bonds and explore their structures to inspire new synthetic methods. Through biochemical and computational approaches, researchers aim to manipulate these enzymes for various applications in medicine and industry.

Dr. Tae-Hee Lee's lab at Penn State focuses on understanding how DNA and histones interact within the nucleosome, which is key to gene regulation. The lab employs cutting-edge single-molecule fluorescence techniques to study these interactions and how chromatin modifications influence gene accessibility. Their work has implications for understanding developmental issues and diseases, especially cancers.