Dr. Amanda Lynn Wolfe's lab focuses on developing new antibiotics to combat multidrug-resistant infections caused by tough Gram-negative bacteria, like Pseudomonas aeruginosa and Acinetobacter baumannii. The lab is researching novel enzymes involved in bacteria's energy production, aiming to find new ways to deliver antibiotics effectively while overcoming bacterial resistance. Their work is critical in addressing the urgent need for new treatment options as current antibiotics become ineffective.