Dr. Martin T. Zanni's lab at the University of Wisconsin-Madison focuses on understanding how a protein called hIAPP forms aggregates that are linked to type 2 diabetes. They use advanced techniques to study the structure of these protein aggregates and their effects on pancreatic cells. By developing models that mimic these conditions, the lab aims to uncover new insights that could lead to better therapies for diabetes.

Dr. Samuel H. Gellman’s lab at the University of Wisconsin-Madison explores the roles of proteins and peptides in cellular processes, particularly how they influence signaling pathways and the formation of membraneless organelles. Their research has applications in understanding diseases like diabetes and neurodegenerative disorders, as they investigate how molecular interactions can affect receptor functions and cellular organization. This work could lead to new therapeutic strategies targeting these critical biological mechanisms.

The Smith Lab at the University Of Wisconsin-Madison focuses on innovative approaches to proteomics, specifically targeting 'proteoforms,' which are unique protein variants shaped by specific amino acid sequences and modifications. Their research aims to identify and analyze these proteoforms in complex biological systems, providing insights into how they influence cell functions and responses related to health and disease. By developing advanced tools and methods, the lab contributes to a broader understanding of cellular mechanisms and supports the scientific community's efforts to address health challenges.

Tina Wang's research lab at the University of Wisconsin-Madison focuses on discovering new cyclic peptides, which are small protein-like molecules with potential therapeutic uses. By developing innovative methods to select cyclic peptides that function effectively within living cells, her lab aims to overcome limitations of traditional peptide discovery techniques. This work could lead to new treatments for diseases that have historically been difficult to target with drugs.

Dr. Tehshik Yoon's lab at the University of Wisconsin-Madison is focused on innovative research in synthetic photochemistry, which utilizes light to drive chemical reactions for biomedical applications. The lab aims to expand the chemical diversity available for developing new medications by discovering novel reaction methods and catalysts that can produce highly reactive intermediates. Their work is crucial for creating life-saving pharmaceuticals and understanding the mechanisms behind these photochemical transformations.