Dr. Margot Mayer-Proschel's lab at the University of Rochester focuses on understanding the role of the Human Herpesvirus 6A (HHV6A) in Alzheimer's disease. The research investigates how a specific gene from the virus, U94A, affects brain cells and may contribute to the development of Alzheimer's by impairing neuronal function and exacerbating pathology. Through cellular models and mouse studies, the lab aims to uncover the mechanisms by which HHV6A infection can influence cognitive deficits and overall disease progression.

Dr. Douglas S. Portman's lab focuses on how biological sex influences the development and function of the nervous system using the model organism Caenorhabditis elegans, a type of roundworm. The research aims to uncover the mechanisms by which sex impacts neuronal circuits and behavior, which could help us understand how these differences manifest in humans and contribute to various neurodevelopmental and neuropsychiatric disorders. By investigating these pathways, the lab hopes to identify potential therapeutic targets for treating sex-specific neurological conditions.