Dr. Bonita J. Brewer's lab at the University of Washington focuses on understanding how cells replicate their DNA accurately. By studying simple organisms like baker's yeast, the lab investigates the coordination between DNA replication and different cell cycle events, which is crucial for maintaining genome stability. Their work is particularly relevant to understanding human diseases, including cancer, that can arise from errors during DNA replication.

Dr. Christine Queitsch's lab focuses on understanding how genetic variations interact with one another to influence complex traits and diseases. Using model organisms such as yeast and the roundworm Caenorhabditis elegans, her research aims to unravel the mechanisms behind these genetic interactions, particularly those involving repetitive DNA elements. By employing advanced genetic techniques and robotics, the lab investigates the impact of these interactions on phenotypes such as lifespan and fitness, contributing to our knowledge of human genetics and potential medical advancements.

Dr. Lea Starita's lab at the University of Washington focuses on understanding genetic variants and their impact on human health. The lab aims to develop innovative approaches to measure how genetic mutations affect diseases, which can aid in diagnosing and treating patients more effectively. By leveraging advanced techniques like saturation genome editing and massively parallel sequencing, the lab strives to turn previously uncertain genetic variants into actionable insights for clinical practice.

Dr. Douglas Fowler's lab at the University of Washington focuses on understanding why cells behave differently under various conditions. They explore how genetic differences, along with environmental factors, contribute to these variations in cell behavior. Their research has led to the development of innovative techniques for assessing the impact of genetic variants on cellular functions, which have broad implications for personalized medicine and disease treatment.

Dr. Alison F Feder's lab focuses on understanding the evolution of solid tumors and their progression to metastasis. By developing innovative methods that combine genetics and computational modeling, the lab aims to reconstruct the historical growth of tumors and predict their future behavior. This research is crucial for creating effective diagnostic tools and improving cancer treatment by providing insights into tumor dynamics and the identification of critical mutations.