Dr. Charles L. Sentman's lab at Dartmouth College focuses on developing innovative therapies for Alzheimer's disease using genetically engineered immune cells. The lab's main project involves creating chimeric antigen receptor (CAR) T regulatory cells that can target and clear harmful amyloid-beta protein plaques in the brain, while reducing inflammation associated with the disease. By enhancing the persistence and activity of these targeted cells, the goal is to improve treatments for Alzheimer's and its neurodegenerative effects.

Dr. James B Bliska's lab at Dartmouth College studies how certain bacterial proteins can help pathogens avoid detection and destabilize the body's immune defenses. They focus on understanding how bacteria, like Yersinia, use specialized mechanisms to disrupt protective pathways in immune cells during infection. This research not only enhances our understanding of bacterial infections but also aims to inform new approaches to boost immune defenses against such pathogens.

Dr. Jennifer Melinda Bomberger's lab at Dartmouth College focuses on understanding the interactions between bacteria and viruses in the context of cystic fibrosis. By studying how Pseudomonas aeruginosa, a harmful bacterium, survives and causes disease in the lungs of cystic fibrosis patients, the lab aims to uncover mechanisms that promote bacterial persistence and chronic infections. Their work could lead to new therapeutic strategies to combat these severe infections.

Dr. Pamela Rosato's lab at Dartmouth College focuses on studying the role of brain resident T cells in Alzheimer's Disease. The lab investigates how these immune cells, particularly a type called CD8+ tissue resident memory T cells, influence disease progression and cognitive decline. By combining mouse models with human tissue analysis, the lab aims to uncover novel therapeutic targets and improve our understanding of neuroinflammation in Alzheimer's and potentially other neurological disorders.

Dr. Joshua J. Obar's lab focuses on understanding how the fungus Aspergillus fumigatus causes chronic lung diseases such as allergic bronchopulmonary aspergillosis (ABPA), particularly in patients with cystic fibrosis. The lab investigates the interactions between this fungus and the immune system, specifically looking at how certain immune cells called alveolar macrophages can either help or hinder the persistence of the fungus in the lungs. This research aims to reveal new ways to treat chronic fungal infections by targeting these immune cells to improve health outcomes for patients.

Dr. Robert Cramer's lab at Dartmouth College focuses on understanding and overcoming fungal infections, particularly those caused by the mold Aspergillus fumigatus, which can be deadly for immunocompromised patients. The lab develops new antifungal drugs that are effective against drug-resistant strains of moulds and studies how certain cancer therapies can influence fungal pathogenicity. They combine chemical biology, genetic analysis, and mouse models to tackle these pressing health issues.

Dr. Claudia V Jakubzick leads a research lab at Dartmouth College that focuses on understanding the role of mononuclear phagocytes in the immune system. Her lab compares the function and gene expression of these immune cells in both humans and mice to identify their similarities and differences. This work aims to improve our understanding of how these cells respond to infections and how this knowledge can be applied to develop better treatments for diseases.

Dr. Yina Hsing Huang's research lab focuses on understanding how certain immune cells, particularly tissue-resident memory T cells, can be sustained and made effective against cancer. The lab investigates innovative strategies for enhancing chimeric antigen receptor (CAR) T cell therapies, which show promise in treating solid tumors by overcoming the immune suppression created by the tumor environment. Their work aims to develop better long-lasting immune responses that can protect individuals from cancer recurrence.

Dr. Mary Jo Turk's lab at Dartmouth College focuses on understanding how a specific type of immune cell, called tissue resident memory T cells, functions in fighting cancer. Their research looks at how these cells are generated, how they move within the body, and their role in preventing cancer recurrence and spread. By studying both mice and human patients, the lab aims to develop strategies to enhance tumor immunity, potentially leading to better cancer treatments.