Dr. Margaret J Lange's lab at the University of Missouri-Columbia focuses on understanding the HIV virus, specifically its capsid protein and its interactions with host cells. Using innovative tools called aptamers—molecular constructs that can bind to specific targets—the lab aims to explore the structure and dynamics of the HIV capsid during replication. Their work seeks to develop new diagnostic technologies and therapeutic targets that can ultimately improve strategies for managing HIV infections.

Dr. Dongsheng Duan's research lab focuses on developing innovative gene therapies for Duchenne muscular dystrophy (DMD), a severe muscle-wasting condition. The lab employs advanced techniques like adeno-associated virus (AAV) delivery systems and CRISPR gene editing to enhance treatment efficacy and safety. By utilizing models, especially canines that closely mimic human DMD, they aim to refine therapeutic approaches and address challenges such as immune responses and treatment longevity.