Dr. Angelo C. Lepore's lab at Thomas Jefferson University focuses on understanding how certain proteins in the nervous system influence pain after spinal cord injuries. Using advanced genetic mouse models, the lab investigates how the EphB2 receptor interacts with NMDA receptors to affect nerve signaling and contribute to chronic pain conditions. The ultimate goal is to discover new ways to manage pain without relying on traditional opioid treatments.

Dr. Davide Trotti's research lab at Thomas Jefferson University focuses on understanding the biological mechanisms behind neurodegenerative diseases, particularly C9orf72-associated ALS and frontotemporal dementia. The lab investigates how genomic instability and the mobilization of transposable elements can lead to neuronal damage and cell death. They also explore potential therapeutic strategies to intervene in these processes and improve outcomes for affected patients.