Dr. Ari Rosenberg's lab at the University of Wisconsin-Madison focuses on understanding how primates perceive and interact with the three-dimensional (3D) world. By studying the neural circuits in the brain associated with visual processing and eye movements, the lab aims to uncover the underpinnings of 3D perception and its implications for both normal cognition and neurodevelopmental disorders. The research combines behavioral experiments and advanced techniques to provide insights relevant to both basic science and potential therapeutic applications.

Dr. Edwin R. Chapman's lab at the University of Wisconsin-Madison studies the molecular mechanics of membrane fusion in neurons, focusing on the release of neurotransmitters. The team utilizes innovative techniques to analyze the dynamics and structure of fusion pores, which are crucial for synaptic transmission. Their research aims to answer key questions about how neurons communicate and the potential implications for treating mental disorders.

Dr. Xinyu Zhao's lab at the University of Wisconsin-Madison focuses on understanding the role of a specific protein, FMRP, in brain development, particularly in primates and humans. This research is crucial for uncovering the mechanisms behind Fragile X Syndrome and other neurodevelopmental disorders like autism. By examining how FMRP influences neuronal maturation and energy metabolism, the lab aims to contribute to the development of better therapies for these conditions.

Robert Fettiplace's lab at the University of Wisconsin-Madison studies the molecular mechanisms that control hearing, particularly focusing on the hair cells in the inner ear. They investigate how specific proteins affect hearing functions and how mutations can lead to hearing loss. The research combines advanced techniques in genetics and electrophysiology to better understand both healthy and damaged hair cells, potentially leading to new insights into hearing impairment treatments.

Dr. Timothy M. Gomez's lab focuses on the development of the nervous system, particularly how neurons extend their axons and dendrites to connect with other neurons. They study how specific signals in the environment of neurons help them navigate through complex tissues during development. By examining structures called invadosomes, which are involved in degrading the extracellular matrix, the lab aims to understand the mechanisms behind axon guidance and potential recovery after nervous system injuries.

Dr. Catherine L. Gallagher's lab focuses on understanding the early changes in the brain associated with Lewy body dementia, a major neurodegenerative condition. By using advanced imaging techniques like PET and MRI, the lab aims to identify how synaptic loss occurs over time in individuals at risk for the disease. This research could lead to new biomarkers for early detection and eventually inform therapeutic interventions.

Dr. Jane S. Paulsen's lab focuses on understanding and improving the diagnosis of a genetic condition called CADASIL, which affects blood flow to the brain and can lead to dementia. The lab investigates how changes in the retina can provide insights into the progression of CADASIL and potentially other forms of vascular dementia. By using advanced imaging techniques, they aim to identify reliable biomarkers that can help in earlier diagnosis and treatment effectiveness in clinical trials.

Dr. Meyer B. Jackson's lab at the University of Wisconsin-Madison examines how cells release signaling molecules through a process called exocytosis. They study the structures involved in this process, known as fusion pores, which regulate the release of neurotransmitters and hormones. By using innovative biophysical techniques, the lab seeks to understand the molecular mechanisms underlying exocytosis and how these processes are altered in various neurological and endocrine disorders.