Dr. Ole Valente Mortensen's lab at Drexel University focuses on understanding how dopamine transporters in the brain work, particularly regarding their regulation and modulation. The lab explores novel compounds that target specific sites on these transporters to develop new treatments for mental health disorders, such as ADHD and depression. By studying the mechanisms of these compounds, the lab seeks to identify new therapeutic options for disorders driven by imbalances in neurotransmitter signaling.

Dr. Alessandro Fatatis's lab at Drexel University focuses on understanding how certain cancer cells thrive in the harsh environment of metastatic prostate cancer, especially when traditional therapies targeting the Androgen Receptor fail. They explore the role of Interleukin-1beta, a signaling molecule that may help cancer cells survive and spread in bone tissue. Through their research, they aim to uncover new treatment strategies that could complement existing therapies and combat advanced prostate cancer more effectively.

Dr. Jacqueline M Barker's lab focuses on understanding how drug use, specifically cocaine exposure, interacts with HIV treatments and hormonal regulation. They explore the behavioral and hormonal impacts of antiretroviral therapy and its effects on the neuroimmune system, aiming to develop strategies to reduce drug cravings and improve treatment outcomes for individuals living with HIV. The research has potential implications for preventing HIV transmission and aiding those struggling with substance use disorders.

Dr. Peter Gaskill's lab at Drexel University focuses on understanding how substance use disorders, particularly stimulant use like cocaine and methamphetamine, interact with HIV to drive inflammation and neurocognitive impairment. The research involves creating human cell models to investigate how dopamine, released due to stimulant use, affects brain cells affected by HIV. By exploring these interactions, the lab aims to find potential therapeutic targets to improve outcomes for individuals living with both HIV and substance use disorders.