Dr. Donald C. Bolser's lab at the University of Florida focuses on understanding how opioids affect the larynx's ability to protect the airways from aspiration, which can lead to pneumonia. The research involves analyzing central nervous system pathways that control laryngeal reflexes, especially during opioid use, to develop new models that can predict the impact of drugs on airway protection. This work aims to provide critical insights into the neurobiology of laryngeal function and improve clinical outcomes for vulnerable populations such as older adults.

Dr. Terence E. Ryan's lab at the University of Florida focuses on understanding a serious condition called chronic limb threatening ischemia (CLTI), which is a critical form of peripheral artery disease. They investigate how fatty fibrosis, an abnormal replacement of muscle with fat and scar tissue, affects blood flow and muscle function in CLTI patients. By studying molecular signaling pathways, particularly the ciliary Hedgehog signaling, the lab aims to identify potential therapeutic targets to improve outcomes for patients suffering from this debilitating condition.

Dr. Christopher D. Vulpe's lab at the University of Florida focuses on how genetic differences influence people's responses to toxic substances. Using innovative CRISPR technology, the lab investigates which specific genes make individuals more or less resilient to environmental toxins. The research aims to enhance our understanding of genetic and environmental interactions, which is crucial for predicting health risks and improving public safety.

Dr. Michelle Gumz's lab studies how our body's internal clock influences blood pressure and kidney function. They focus on a key protein called PER1, which helps regulate these functions. By understanding how disruptions in this clock can lead to conditions like salt-sensitive hypertension and kidney disease, the lab aims to find new treatments to help patients with cardiovascular issues.

Dr. Zheng Wang's lab at the University of Florida focuses on understanding the relationship between autism spectrum disorder (ASD) and the early onset of dementia in autistic adults. The research investigates how neurocognitive functions, brain imaging, and plasma biomarkers can reveal signs of dementia in middle-aged autistic individuals. By studying these factors, the lab aims to contribute to better diagnosis and treatment strategies for dementia in this vulnerable population.

Dr. Orlando Laitano's lab at the University of Florida focuses on understanding and treating muscle weakness and dysfunction caused by sepsis, a severe infection that can lead to significant muscle loss and impairment. The research aims to identify the role of specific enzymes in this process and test new strategies to promote muscle recovery in affected patients. By exploring how sepsis affects muscle cells, the lab hopes to develop better therapeutic approaches to enhance recovery in critically ill patients.

Dr. Christiaan Leeuwenburgh's lab at the University of Florida focuses on understanding how iron regulation and mitochondrial function affect the physical capabilities of older adults. Through research, they aim to figure out why some older adults experience a decline in their ability to move and function compared to others. By measuring various biological factors over time, the lab hopes to find ways to support healthier aging and improve quality of life for older individuals.

Dr. David E Vaillancourt's lab is focused on advancing the early identification of Parkinson's disease and related disorders. They study a condition called REM behavior disorder (RBD), which often precedes Parkinson's, using various innovative methods to detect preclinical signs of disease. Their goal is to find biomarkers and behavioral indicators that could help diagnose and treat Parkinsonism much earlier than is currently possible.

Dr. Rachael D. Seidler's lab focuses on understanding how the brain controls movement and thinking, particularly in older adults at risk for Alzheimer's disease and related conditions. By studying the relationships between walking, cognition, and the brain's vestibular system, the lab aims to identify early indicators of cognitive decline and develop interventions to improve mobility and cognitive function. Their research could help people maintain their independence as they age.