Dr. Janice J. Endsley's lab at the University of Texas Medical Branch in Galveston focuses on understanding how certain immune cells called macrophages respond to lung infections, particularly those caused by Mycobacterium tuberculosis (the bacterium that causes tuberculosis). By studying the role of specific proteins in these cells, the lab investigates how infections and conditions like HIV can affect the immune response and inflammation. The goal is to find new ways to enhance immune function and improve treatment strategies for tuberculosis and related infections.

Dr. Ashok K Chopra's lab focuses on developing innovative vaccines against the plague by studying the immunological responses in both mice and non-human primates. By identifying new virulence genes of the plague bacteria, Yersinia pestis, the lab aims to create safer and more effective vaccines than those currently available. The research not only enhances our understanding of how to combat this deadly disease but also seeks to address public health risks posed by antibiotic-resistant strains.

Dr. Fernanda Laezza's lab focuses on understanding and treating psychiatric disorders by investigating brain circuits and their behaviors. The research emphasizes developing novel chemical probes that target specific protein interactions in neurons, particularly related to reward mechanisms. By studying how these probes influence neuronal activity, the team aims to uncover new therapeutic strategies for various mental health conditions.

Dr. Jere McBride's research focuses on understanding how the intracellular bacterium Ehrlichia chaffeensis, which causes a serious tick-borne disease in humans, manipulates host cell machinery to enhance its survival and replication. The lab investigates the role of specific proteins that Ehrlichia secretes to alter RNA splicing processes in human cells, particularly those involved in immune responses. By exploring these molecular interactions, the research aims to uncover new therapeutic strategies to combat this pathogen and similar intracellular infections.

Dr. Giulio Taglialatela's research lab focuses on understanding the early molecular events that cause Alzheimer's Disease (AD), specifically how different forms of toxic tau protein impact synapses in the brain. The lab investigates why some individuals can remain cognitively healthy despite having signs of AD pathology, aiming to develop new therapies that protect synapses from tau-induced damage. Through this work, the lab seeks to uncover the mechanisms behind synaptic resilience and vulnerability in neurological diseases.

Dr. Tian Wang's lab focuses on developing innovative vaccines to combat COVID-19, particularly using a novel approach involving porous silicon microparticles. They aim to enhance both systemic and mucosal immunity against SARS-CoV-2 variants, making vaccination more effective through different delivery methods. The research holds potential for long-term protection against viral infections and improving public health responses to pandemics.