Dr. Monica Venere's lab focuses on understanding a specific type of brain tumor called ependymoma, particularly those driven by the ZFTA-RELA fusion. These tumors are especially challenging to treat, and the lab is investigating a protein called FACT that is involved in maintaining the cancerous state of these tumors. By exploring how FACT contributes to tumor growth and its potential as a drug target, the lab aims to develop new therapies that could significantly improve patient outcomes.

The research lab of Dr. Hongjun Fu at Ohio State University focuses on understanding the mechanisms behind neuronal vulnerability in Alzheimer's disease, particularly regarding a protein called WFS1. They explore how deficiencies in this protein contribute to the accumulation of toxic tau proteins in neurons, leading to cognitive decline. By studying the pathways involved, they aim to uncover potential therapeutic targets for treating and preventing neurodegenerative diseases.

Dr. Lihua Ye’s research lab at Ohio State University focuses on how microorganisms in the gut can influence brain function and contribute to anxiety and disorders such as irritable bowel syndrome (IBS). The lab explores the role of specific gut bacteria and their interactions with gut cells that produce serotonin, investigating the cellular and signaling pathways involved. By understanding these connections, Dr. Ye aims to identify new treatments that target gut-brain communication and improve health outcomes for individuals with neurological and gastrointestinal disorders.