Dr. Binhua P Zhou's lab focuses on understanding and combating triple-negative breast cancer (TNBC), a highly aggressive form of cancer with poor prognosis. The research aims to investigate how a specific enzyme, nicotinamide N-methyltransferase (NNMT), helps TNBC cells survive under stress and contributes to their spread in the body. By targeting NNMT with specially designed inhibitors, the lab seeks to develop new treatment strategies to improve outcomes for patients with TNBC.

Dr. Wang-Xia Wang’s lab at the University of Kentucky focuses on understanding how microRNAs influence neuroinflammation and the role they play in Alzheimer's disease. The lab is particularly interested in a specific microRNA, miR-223, which affects the ApoE pathway, a critical component linked to neuroinflammation and sex-related differences in disease response. Through various experimental techniques, the lab aims to develop new therapeutic strategies that could improve treatment outcomes for Alzheimer's disease, especially in female patients who may be disproportionately affected by these conditions.

Dr. Michele Staton's lab at the University of Kentucky focuses on reducing overdose deaths among women, particularly those affected by the criminal justice system in rural areas. They are researching innovative strategies to support these women as they transition from jail back into their communities, aiming to improve their access to treatment and decrease overdose risks. The lab combines behavioral health approaches with practical support interventions to empower women during this critical period.

Dr. Hsin-Sheng Yang's lab at the University of Kentucky focuses on understanding the mechanisms behind lung cancer, particularly how certain proteins interact to control tumor growth. The research investigates the role of a tumor suppressor protein called Pdcd4 and its interaction with Rictor, which is involved in cancer cell growth. By exploring these interactions, the lab aims to develop new therapeutic strategies targeting lung cancer, especially forms with elevated levels of Rictor.