Dr. Lulu Jiang's lab focuses on understanding the mechanisms behind Alzheimer's disease, particularly how RNA modifications affect the disease's progression. They study how tau protein aggregates can alter RNA methylation, leading to neuronal dysfunction. The lab employs innovative techniques to explore new therapeutic strategies that could help in treating Alzheimer's and related disorders.

Elias T Spiliotis’ lab at the University of Virginia studies how membrane transport within cells is regulated, particularly in polar cells like neurons and epithelial cells. Their research aims to uncover the roles of septins, a unique family of proteins, in controlling the direction and movement of cell components. By understanding these mechanisms, the lab hopes to find new insights that can lead to better therapies for diseases linked to cellular transport dysfunctions, such as neurodegeneration and cancer.

Dr. Brant Isakson's lab at the University of Virginia focuses on understanding the mechanisms that regulate blood pressure and vascular health, particularly through the actions of specific proteins in the kidneys and blood vessels. Their research investigates how renin, a key hormone in blood pressure regulation, is released and how inflammation affects the barrier function of blood vessels, especially during conditions like sepsis. By exploring the interactions between different proteins, the lab aims to find potential therapeutic targets for hypertension and other cardiovascular diseases.

Dr. Swapnil K. Sonkusare's lab at the University of Virginia focuses on understanding how calcium signaling in blood vessels affects blood pressure regulation, particularly under conditions like hypertension. They explore specific mechanisms in smooth muscle and endothelial cells that influence blood vessel dilation and constriction, which can help identify potential treatments for high blood pressure. Their research may lead to novel therapies aimed at improving vascular health and lowering cardiovascular risks.

Dr. Stephen S. Rich's lab focuses on understanding how genetic factors contribute to Type 1 diabetes (T1D) through a process called alternative splicing. By analyzing blood samples and genetic data from children at risk of T1D, the lab aims to uncover how different genes and their variants can influence the immune response and lead to diabetes. This research has important implications for early diagnosis and potential therapies for T1D.

Dr. Joshua D. Wythe's lab at the University of Virginia focuses on understanding brain arteriovenous malformations (bAVMs), which are dangerous blood vessel abnormalities that can lead to stroke, especially in children and young adults. The lab investigates the cellular and molecular mechanisms behind these conditions, particularly looking at genetic mutations and endothelial cell behavior. By using animal models, the team aims to find safer, drug-based treatments for these serious vascular issues.