Luk Lab
Edward E Luk · Stony Brook, New York
Stony Brook University · Biochemistry
Research focus
Dr. Edward E Luk's lab at Stony Brook University focuses on understanding unique structures of chromatin, which are crucial for regulating gene expression and cellular processes. By studying specific histone variants and their roles in transcription and chromatin formation, the lab aims to uncover how these structures impact cellular behavior and may be linked to diseases like cancer. The research involves advanced biochemical techniques and models to explore these processes at a molecular level.
chromatingene expressiontranscriptionhistone variantsbiochemical techniquesgenomic researchtelomeresnucleosomesstructural biology
Research aims
5AIM 01Investigate how histone variant H2A.Z targets specific genomic sites.
AIM 02Examine the role of R-octasomes in telomeric gene silencing.
AIM 03Explore the interplay between histone modifications and transcription.
AIM 04Develop methodologies to assess the function of variant chromatin structures.
AIM 05Understand the biophysical properties of chromatin and its role in gene regulation.
Skills the lab values
PCRbiochemical assayscell culturegenome editingcryo-electron microscopyin vitro transcription assaysgenetic analysishigh-throughput sequencingbioinformatics
Output against the department
36publicationsbottom 3% of the department388th of 402
most publishedleast published
2.4kcitationsbottom 9% of the department365th of 402
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.