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Joe Verghese — Dr. Joe Verghese's lab focuses on understanding cognitive decline and dementia, particularly among immigrant populations such as Kerala Americans. The research explores how cultural and social factors influence dementia risk and aims to improve cognitive assessments in primary care settings. By studying the unique demographic of first-generation immigrants, the lab seeks to uncover insights that could aid in early detection and management of cognitive impairment.
Erwin London — Erwin London's lab explores the intricate structure and function of cell membranes, focusing on how the composition of lipids affects cellular processes and responses. Using innovative techniques, the team investigates how the organization of membrane lipids influences the behavior of membrane proteins, particularly receptors that play crucial roles in cellular signaling. The lab's research has implications for understanding disease mechanisms and improving vaccine design.
Wei Zhao — Dr. Wei Zhao's lab focuses on enhancing breast cancer detection through the development of a new imaging technology called the dual-layer flat-panel detector. By creating a system that captures two x-ray images at different energy levels, they aim to improve the accuracy of breast cancer screenings while reducing patient motion artifacts. The lab is dedicated to moving these innovations from the research phase into clinical settings to benefit patients directly.
Donghui Zhu — Dr. Donghui Zhu's lab at Stony Brook University focuses on developing innovative bioresorbable materials for medical applications, particularly in gastrointestinal and cardiovascular treatments. The lab is exploring new types of staples and stents made from biodegradable metals like zinc to improve patient outcomes and reduce complications associated with traditional materials. Their work aims to create safer and more effective solutions that promote healing while minimizing the need for additional surgeries.
Ke Jian Liu — Dr. Ke Jian Liu's lab at Stony Brook University focuses on understanding how intracerebral hemorrhage (ICH) causes brain damage, specifically through a compound called zinc protoporphyrin (ZnPP). Their research investigates the relationship between tissue hypoxia, oxidative stress, and ZnPP formation in the brain after hemorrhage. The lab aims to explore whether repurposing certain FDA-approved drugs can provide new therapeutic options to reduce brain injury caused by ICH.
Maurizio Del Poeta — Dr. Maurizio Del Poeta's lab at Stony Brook University explores the biology of harmful fungi, particularly how they infect immunocompromised patients, such as those with HIV. The research focuses on understanding the immune response to fungal infections and developing novel antifungal treatments that target specific enzymes unique to fungi, which can help improve patient outcomes. By utilizing mouse models and high-throughput screening, the lab aims to provide new insights and therapeutic strategies against invasive fungal infections.
James B Konopka — Dr. James B. Konopka's lab focuses on understanding how the fungal pathogen Candida albicans increases its ability to cause infections. By examining the role of the plasma membrane in helping this fungus survive harsh conditions and grow invasively in the human body, the team aims to uncover new strategies for developing better antifungal treatments. Their research combines genetics and microbiology to explore how these mechanisms can be targeted in future therapies.
Erich R Mackow — Dr. Erich R Mackow's lab focuses on understanding how the Powassan virus (POWV), a tick-borne virus that can cause severe brain damage, infects the central nervous system, particularly in older individuals. The lab studies the differences in how the virus affects young versus aged mice and explores potential treatments to prevent serious neurological damage. By using advanced techniques like genetic engineering and single-cell RNA sequencing, the lab aims to uncover the mechanisms of the virus's neurovirulence and develop strategies that could lead to vaccines or therapies for at-risk populations.
Richard Z Lin — Dr. Richard Z Lin's lab focuses on developing new drugs to prevent a serious heart condition known as acquired Long Q-T Syndrome (aLQTS), which can cause dangerous arrhythmias. The research aims to identify and test compounds that can safely shorten the electrical signals in heart cells, preventing long-term heart issues associated with certain medications. By studying ion channels and their effects on heart function, the lab seeks to create therapies that are both effective and minimize side effects.