Loading university
Alison M Goate — Dr. Alison Goate's lab at the Icahn School of Medicine focuses on understanding the role of microglia in Alzheimer's disease. They are investigating how specific genes and signaling pathways in these immune cells can protect against neurodegeneration and how dysfunctional activation of microglia might contribute to the progression of the disease. The ultimate aim is to identify therapeutic targets that could prevent or delay the onset of Alzheimer's disease.
Adolfo Garcia-Sastre — Dr. Adolfo Garcia-Sastre's lab at the Icahn School of Medicine focuses on studying how viruses, particularly SARS-CoV-2 and other coronaviruses, adapt to human hosts. By utilizing systems biology approaches and advanced modeling techniques, the lab aims to uncover biological networks that influence viral replication and disease severity. Their research seeks to identify potential biomarkers and therapeutic targets that can help in predicting disease outcomes and developing new treatments.
Patrick R Hof — Dr. Patrick Hof's lab is focused on understanding how cardiovascular health impacts brain health as humans age, particularly in comparison with great apes like chimpanzees and gorillas. The research aims to uncover why humans are more prone to cognitive decline and specific heart diseases than our closest relatives. By studying the differences in brain and heart aging between these species, the lab hopes to provide insights into how we can promote healthier aging in humans.
Judy H. Cho — Dr. Judy H. Cho's lab at the Icahn School of Medicine focuses on understanding the genetic and molecular mechanisms behind inflammatory bowel disease (IBD), particularly Crohn's disease. The research explores how specific genetic mutations affect blood cells and tissue response, especially in challenging cases like perianal fistulae. Through advanced techniques like single-cell transcriptomics and multi-omic analysis, the lab aims to identify new therapeutic targets and improve patient outcomes in IBD.
Zahi A. Fayad — Dr. Zahi A. Fayad's research lab focuses on improving outcomes in organ transplantation and understanding the effects of stress on cardiovascular disease. The lab investigates how innate immune responses, called trained immunity, can influence organ rejection and explores advanced imaging techniques for assessing heart conditions like cardiac sarcoidosis. Their goal is to create better therapies for transplant recipients and improve diagnostic methods for heart disease.
Helen S Mayberg — Dr. Helen S. Mayberg's lab focuses on developing innovative treatments for patients with treatment-resistant depression using a technique called deep brain stimulation (DBS). By studying how the brain's electrical signals relate to patients' moods and behaviors, the lab aims to create a method that allows doctors to make more objective treatment decisions. This research could help improve the effectiveness and personalization of depression therapies, potentially benefiting many who struggle with this condition.
Bin Zhang — The research lab led by Dr. Bin Zhang at the Icahn School of Medicine focuses on understanding Alzheimer's disease (AD) through the lens of cellular aging and genetic factors. By investigating the roles of senescent cells and the interaction between sex and the APOE gene, the lab aims to uncover new therapeutic targets for AD. Their innovative approaches include advanced single-cell sequencing techniques and multi-omics data analysis, enabling them to create personalized strategies for AD treatment and prevention.
Robert J Desnick — Dr. Robert J. Desnick's lab focuses on developing innovative treatments for rare genetic disorders, particularly Congenital Erythropoietic Porphyria (CEP). They are conducting clinical trials to test an oral medication, ciclopirox olamine, which aims to improve the enzyme activity deficient in patients with CEP. This research could potentially transform the lives of individuals with this challenging condition by alleviating symptoms and improving overall quality of life.
Zhenyu Yue — Dr. Zhenyu Yue's lab at the Icahn School of Medicine focuses on understanding how autophagy helps protect neurons in the brain. They study how the process of autophagy, which recycles damaged cellular components, can go wrong in diseases like Alzheimer's and Parkinson's. The lab aims to discover ways to improve neuroprotection through understanding these mechanisms, potentially leading to new treatments for neurodegenerative diseases.