Dr. Federica Accornero's lab at Brown University focuses on uncovering the molecular mechanisms that regulate aging and heart function through post-transcriptional modifications of RNA. The lab explores how specific RNA methylation processes, particularly involving the enzyme METTL3, influence gene expression related to aging and cardiac health. By studying these processes, the lab aims to identify potential therapeutic targets for age-related diseases and heart failure.

Dr. Jill Kreiling's lab at Brown University is focused on developing non-invasive biomarkers for Alzheimer's disease and related disorders. The team is exploring salivary extracellular vesicles to identify RNA and protein patterns that help predict the risk of developing these neurodegenerative diseases. Their work aims to create accessible testing methods that could lead to earlier interventions for patients before serious symptoms arise.

Walter J Atwood's lab at Brown University focuses on understanding Progressive Multifocal Leukoencephalopathy (PML), a severe brain disease caused by the JC virus, especially in patients with weak immune systems like those with AIDS or undergoing certain therapies. The lab investigates how the virus persists in the body and spreads to the brain, aiming to identify early biomarkers for PML and develop new treatment strategies. The research is important for improving outcomes for vulnerable populations affected by this fatal disease.

Dr. Stephen L. Helfand's lab at Brown University focuses on understanding a rare genetic disorder resulting in severe epilepsy caused by mutations in the SLC13A5 gene. The lab utilizes advanced models, including fruit flies and mice, to explore how these mutations disrupt brain functions and develop potential treatments. Their research is crucial for linking genetics to the observed symptoms in patients, paving the way for new therapeutic strategies.

Dr. Michelle R. Dawson's lab at Brown University focuses on understanding how some cells in epithelial ovarian cancer can resist treatment and spread within the body. Her research investigates the role of energy metabolism in cancer cells, particularly how they switch between using different energy sources when under stress. By studying these processes, particularly in a specialized 3D culture model, the lab aims to discover new ways to target and potentially treat this aggressive cancer more effectively.

Dr. Eric Morrow's lab at Brown University investigates the biological mechanisms behind neurodevelopmental and neurodegenerative disorders. The research focuses on genetic factors, particularly copy number variations (CNVs), that increase the risk of conditions like autism. By studying animal models and human stem cells, the lab seeks to understand how these genetic changes affect brain development and neuronal health, with the goal of developing new therapeutic strategies.

Gary Wessel's lab at Brown University focuses on understanding how primordial germ cells are formed and regenerated during early development in animals like sea urchins and sea stars. Unlike mammals, these unique organisms allow the lab to study germline biology with advanced techniques that reveal insights into sexual reproduction and regeneration. The research aims to decode the mechanisms behind germ cell formation and explore ways these processes can be innovatively manipulated in the lab.