Dr. Martin Graef's lab at Cornell University studies how cellular aging works, particularly through the lens of autophagy, a process where cells clean out damaged components. Using yeast as a model organism, the lab investigates how different forms of autophagy can affect lifespan and aging. The goal is to uncover new biological mechanisms that could help improve health as we age and might one day inform therapies for age-related diseases.

Dr. John T. Lis's lab at Cornell University focuses on understanding how enhancers and promoters work together to regulate gene expression in the human genome. The team is investigating the role of DNA sequences that control these interactions, which are crucial for understanding how genes are turned on and off in various conditions. By mapping these elements and assessing their functions, they aim to provide insights applicable to both normal biology and diseases.

Jun Liu's lab at Cornell University studies the bone morphogenetic protein (BMP) signaling pathway, which is crucial for proper development and function in organisms. Using the model organism C. elegans, the lab investigates how various proteins and genetic factors regulate BMP signaling and its implications for diseases such as cancer and cardiovascular conditions. Their research aims to uncover the mechanisms behind BMP regulation, which could lead to new therapeutic strategies for disorders related to faulty BMP signaling.

Dr. B Franklin Pugh's lab at Cornell University investigates how genes are regulated in yeast and humans. By starting with the simpler yeast model, they aim to understand the fundamental mechanisms of gene regulation that apply across all eukaryotic life. Their research focuses on mapping the intricate interactions between proteins and DNA, which can lead to improved diagnostics and therapies for diseases in humans.

Dr. Cedric Feschotte's lab at Cornell University studies transposable elements (TEs), which are DNA sequences that can change their position within the genome. These elements are critical for understanding evolution and genetic variation, as they can influence gene expression and contribute to cellular functions. By examining the role of young TEs in human and zebrafish development, the lab aims to uncover their significance in processes like embryonic growth and pregnancy, potentially leading to new insights into diseases such as neurodevelopmental disorders and complications during pregnancy.

Dr. Tudorita Tumbar's lab at Cornell University focuses on understanding the cellular and molecular organization of the skin's inter-follicular epidermis, particularly how it renews and repairs itself. The research looks at how different types of skin cells behave and interact, particularly under conditions like UV exposure. The lab also investigates the mechanisms of gene regulation in skin cells, offering insights into how genes are expressed during skin development and healing. Overall, the work aims to shed light on how skin maintains health and responds to injury.