The lab of Dr. Wesley I. Sundquist at the University of Utah focuses on understanding the molecular mechanisms behind HIV-1 virus assembly and release from host cells. By studying the roles of specific host proteins and cellular pathways, the research aims to identify how HIV-1 exploits these mechanisms and how certain proteins can inhibit viral release. This research not only targets HIV but also provides insights into other enveloped viruses and potential therapeutic strategies against viral infections.

Dr. Erhu Cao's lab focuses on understanding the structures and functions of proteins related to polycystic kidney disease and cation-chloride cotransporters, which play important roles in kidney function and brain activity. By studying these proteins, the lab aims to uncover mechanisms behind genetic disorders and explore new ways to treat conditions like hypertension, edema, and congenital heart defects. The research combines biochemical and structural analysis to inform the development of targeted therapies.

Dr. Owen Pornillos' lab focuses on understanding how certain proteins called TRIM5 proteins protect cells against viruses like HIV. They study the structure of these proteins and how they interact with viral components to prevent infection. Through advanced techniques, their research aims to uncover the details of how TRIM5 proteins function, which could lead to new ways to combat HIV/AIDS.