Patricia M Kane's lab focuses on studying V-ATPases, which are important protein pumps that help acidify cellular compartments in all eukaryotic cells. The lab investigates how these pumps are regulated and their roles in diseases like cancer, epilepsy, and Alzheimer's. By understanding the mechanisms behind V-ATPase function, the lab hopes to develop better therapeutic strategies for diseases linked to their dysfunction.

Dr. Stewart Loh's lab at Upstate Medical University focuses on understanding systemic amyloidosis, a serious condition caused by misfolded proteins accumulating in various organs like the kidneys and heart. The lab uses innovative microfluidic devices that mimic kidney blood flow to study how shear stress affects protein misfolding and aggregation. The ultimate goal is to create early diagnostic tests using biosensors that can detect these protein aggregates in patients' blood and urine.