Dr. Silvia Guglietta's lab focuses on understanding the role of the complement C3a receptor in the development of colorectal cancer (CRC) and its effects on the intestinal barrier and the microbiome. By exploring the communication between immune cells and epithelial cells in the intestines, her research aims to uncover how inflammation contributes to CRC initiation and progression. This research holds promise for improving strategies for CRC prevention and treatment through a better understanding of immune system interactions.

Stephen A. Duncan's lab focuses on discovering new drugs that can lower cholesterol production in the liver, which is crucial for addressing high cholesterol issues in patients. By using a type of liver cell derived from human stem cells, the lab investigates the effects of several small molecules that inhibit a specific enzyme called carboxylesterase 1. These findings could lead to treatments for conditions like familial hypercholesterolemia and fatty liver disease without the side effects associated with current cholesterol medications.

Dr. Hainan Lang's lab at the Medical University of South Carolina focuses on understanding how auditory processing deficits may relate to autism spectrum disorders (ASD). By studying the effects of the MEF2C gene on neuronal and immune system functions, the lab explores how these factors might contribute to communication challenges in children with ASD. The research integrates animal models and advanced techniques to uncover potential therapeutic strategies.

Dr. Russell Norris's lab focuses on understanding mitral valve prolapse (MVP), a condition that can severely affect heart health. The lab investigates how MVP can lead to serious complications like left ventricular fibrosis and arrhythmias, emphasizing the importance of early diagnosis and treatment. By exploring the biological mechanisms behind MVP, the team aims to improve patient outcomes and develop better prevention strategies.

Dr. Hongkuan Fan's lab at the Medical University of South Carolina focuses on understanding how a specific type of brain cell, called pericytes, is involved in the development of Alzheimer's disease. They study how disruptions in blood flow and the blood-brain barrier affect brain function and contribute to cognitive decline in Alzheimer's. The lab is exploring a molecule called Fli-1 that may play a crucial role in these processes, with the hope of developing new treatment strategies for Alzheimer's disease.

Dr. Gerald W. Dorn's lab focuses on understanding how mitochondria function and adapt in heart cells, especially during conditions like cardiomyopathy and heart failure. They explore the role of a protein called Mitofusin 2 in regulating mitochondrial dynamics and metabolism, aiming to find new therapeutic approaches to improve heart health. The research combines basic science and translational applications to address critical challenges in heart disease treatment.

Dr. Amy C Engevik's lab focuses on understanding how specific proteins in our intestines influence gut health, particularly in the context of inflammatory bowel disease (IBD). The team studies a protein called Myosin 5b, which helps transport key enzymes that protect our intestines from inflammation. By exploring the relationship between Myosin 5b and intestinal alkaline phosphatase, they aim to uncover new insights that could lead to better treatments for IBD.