Dr. Amy E. Moran's lab investigates how the androgen receptor affects T cell function, particularly in the context of cancer immunotherapy. They are exploring the mechanisms by which this receptor influences T cell behavior and its implications for improving treatment outcomes in cancers like prostate cancer. The research integrates animal models and chromosome-level analysis to better understand these processes and potentially augment immunotherapy effectiveness.

Dr. Laurie King's lab at Oregon Health & Science University focuses on improving balance and mobility in older adults, particularly those suffering from Parkinson's disease. The team explores innovative rehabilitation methods using wearable technology for remote assessments and tele-rehabilitation to maximize independence and reduce fall risks. They aim to assess how effective these strategies are in the homes of patients while addressing challenges highlighted by the COVID-19 pandemic.

Dr. Megan K Ruhland's lab at Oregon Health & Science University studies how male and female immune systems respond differently to cancer, especially in melanoma. The lab focuses on understanding how androgen receptors in specific immune cells called dendritic cells influence the body's ability to fight tumors. By using innovative mouse models, the team aims to uncover how these differences impact T cell activation and vaccine effectiveness against cancer.

Dr. Jonah B. Sacha's lab focuses on understanding how certain immune responses can lead to the cure of HIV. By studying the effects of allogeneic hematopoietic stem cell transplantation in both cured HIV patients and macaques, the lab aims to uncover specific T cell responses that can effectively eliminate the viral reservoir. Their research has significant public health implications, as it could lead to new therapeutic methods for HIV treatment.

Dr. Yabing Chen's research lab at Oregon Health & Science University focuses on understanding the links between vascular health and cognitive function, particularly in age-related conditions like vascular dementia and Alzheimer's disease. The lab investigates how specific proteins influence the behavior of vascular cells and how these changes can lead to broader implications for cardiovascular disease and dementia. By exploring genetic and molecular mechanisms, the research aims to develop better treatment strategies for these conditions.

Dr. Melissa H. Wong's lab focuses on understanding how certain cancer cells spread from primary tumors to other parts of the body, which is a major challenge in treating cancer. They study a specific type of cancer cell, known as circulating hybrid cells, that may play a critical role in metastasis. Through advanced analyses and techniques, the lab aims to uncover the biological mechanisms that allow these cells to disseminate, which could lead to improved treatments for patients with colorectal cancer and other metastatic diseases.