Dr. Sadek Nehmeh's lab focuses on advancing brain imaging technology to enhance the diagnosis and monitoring of neurological disorders and brain tumors. His team is developing a new ultra-high performance PET scanner that promises superior imaging capabilities compared to existing technologies, enabling early diagnosis and treatment of brain diseases. With a collaborative approach, the lab combines expertise in engineering, imaging, and clinical applications to create a cutting-edge tool for neurology and neuro-oncology.

Dr. Qolamreza Ray Razlighi's lab focuses on understanding Alzheimer's Disease (AD) by developing a new tool called the Tau Progression Index (TPI). This tool will help predict how the disease progresses in individuals based on brain imaging data and cognitive assessments. Through this research, the lab aims to enhance personalized medicine approaches for Alzheimer's, providing better prognostic information for patients and their families.

Dr. Benedict Shek Hang Law's lab at Weill Medical College focuses on developing innovative therapies for bladder cancer, particularly for patients who can't undergo standard invasive treatments. His research aims to improve drug delivery methods to ensure higher effectiveness and lower recurrence of cancer, using novel peptide-based systems that minimize the invasive techniques currently used.

Dr. Tracy A. Butler's lab focuses on understanding how the brain clears toxins after traumatic brain injuries (TBI), which can lead to neurodegenerative diseases like Alzheimer's. By using advanced imaging techniques soon after injury, the lab investigates the dynamics of harmful proteins that accumulate in the brain and how they correlate with recovery. Ultimately, their goal is to improve recovery from TBI and reduce the risk of future illnesses.

Dr. Alexey Dimov's lab focuses on improving the detection of hemorrhagic cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). By developing a technique called quantitative susceptibility mapping (QSM), the lab aims to better identify patients at risk for rapid kidney function decline and optimize treatment strategies. This research has the potential to significantly enhance patient care and outcome by providing earlier and more accurate risk assessments.

Dr. Holly Prigerson's lab focuses on improving the quality of end-of-life care for cancer patients and their families. Her research addresses the emotional and psychosocial challenges faced by patients in the last stages of their lives, aiming to educate oncologists on better communication about prognosis and treatment options. The lab also emphasizes the role of caregivers and healthcare chaplains in providing comprehensive support, while developing interventions to alleviate patient distress and promote advance care planning.

Dr. Moustafa Gabr's lab at Weill Medical College focuses on developing small molecule therapies to tackle challenging diseases like Alzheimer's, inflammatory bowel disease (IBD), and glioblastoma. They utilize an innovative platform to identify molecules that can modulate the immune response, aiming to enhance treatment efficacy and minimize side effects compared to traditional biologics. The lab emphasizes harnessing the power of small molecules to interact with key immune receptors to improve therapeutic outcomes.

Dr. Amirhossein Goldan's lab focuses on developing advanced imaging technologies for early diagnosis of Alzheimer's disease. They work on a portable, high-resolution PET scanner that improves the detection of tau protein deposits in the brain, which are indicative of Alzheimer's. This innovative approach aims to enhance accessibility to brain imaging and improve the accuracy of Alzheimer's diagnosis.

Dr. Jeffrey Ketterling's research lab focuses on improving imaging techniques to study heart diseases in mice. By developing advanced ultrasound technology, the lab aims to detect early signs of heart dysfunction before visible changes occur. This work is crucial for understanding how blood flow patterns affect heart health and could lead to better treatment approaches for patients suffering from heart disease.

Dr. Laura Beth Johnson Mcintire's lab focuses on understanding how lipid metabolism changes in the brain due to Alzheimer's disease. They aim to create a detailed atlas of lipid distribution in the brain to help identify key changes that could lead to new biomarkers or therapeutic targets for Alzheimer's. By studying both human brains and mouse models, the lab seeks to connect findings in lipid dysregulation to cognitive decline and disease progression in Alzheimer's disease.

Dr. Jonathan Mamou's lab focuses on improving the detection and evaluation of lymph nodes, particularly in determining whether they harbor metastatic cancer. By leveraging advanced quantitative ultrasound techniques, his research aims to create better diagnostic tools that can differentiate between cancerous and benign conditions in lymph nodes during routine medical procedures. This work not only seeks to enhance cancer staging but also to facilitate more appropriate treatment strategies for patients.

Dr. Paul K. Maciejewski's lab focuses on improving end-of-life care for patients with advanced cancer by addressing their spiritual needs. The lab investigates how integrating healthcare chaplains and faith community support can enhance patients' spiritual wellness and ultimately lead to better decision-making and care at the end of life. By conducting controlled trials and qualitative interviews, the lab seeks to understand the impact of spiritual care on patients' experiences in oncology settings.

Dr. Bobak Mosadegh's lab focuses on improving the care of dialysis patients by using artificial intelligence to screen for problems in their blood vessels. Specifically, they are working on a technology that listens to sounds from a digital stethoscope to detect issues like stenosis in arteriovenous fistulas, which are critical for providing dialysis. By validating this AI tool against traditional imaging methods, the goal is to enhance patient outcomes and reduce unnecessary interventions.

Dr. Sandra Demaria's lab focuses on understanding how radiation therapy can enhance the immune response against tumors, particularly in the context of cancer immunotherapy. They are investigating how certain immune cells, called dendritic cells, are influenced by radiation and can help improve the effectiveness of treatments that unleash the immune system against cancer. The team aims to unravel the complex interactions between radiation, immune cells, and tumors to find new ways to boost patient responses to therapy.

Dr. Laura Santambrogio's lab focuses on understanding a newly discovered compound derived from tryptophan metabolism called 3HKA, which exhibits anti-inflammatory properties. They study how this compound interacts with immune cells, proposes its potential therapeutic applications for autoimmune diseases like psoriasis and lupus, and develop similar compounds to enhance immunomodulation. The lab integrates techniques from biochemistry and immunology to explore how metabolism influences immune system behavior.

Dr. Thanh Nguyen's lab focuses on enhancing MRI techniques to better predict stroke risks associated with unstable carotid plaques. The research utilizes a novel imaging method called quantitative susceptibility mapping (QSM) to differentiate between dangerous hemorrhages and benign calcifications in arterial plaques. By improving the accuracy of stroke risk assessment through advanced imaging, the lab aims to contribute to more personalized and effective stroke prevention strategies.

Dr. Claire Isabelle Vanpouille-Box's lab studies glioblastoma, a challenging brain cancer, focusing on how radiation therapy affects tumor metabolism and immune responses. The lab investigates how glioblastoma cells change their metabolism to produce fatty acids and how this impacts the immune system, potentially leading to therapy resistance and tumor recurrence. By understanding these mechanisms, the research aims to find new ways to boost the immune response against these tumors after radiation treatment.

Dr. Yi Wang's lab focuses on developing innovative MRI techniques to improve the diagnosis and treatment of neurological conditions such as stroke and Alzheimer's disease. They use fluid mechanics principles to enhance tissue perfusion imaging and create new methods for mapping oxygen metabolism in the brain. By refining these MRI-based tools, the lab aims to provide more accurate and reliable assessments of brain health, ultimately aiding in patient management and clinical decision-making.