Dr. Dongbing Lai's lab focuses on understanding the genetics behind alcohol use disorder (AUD), a significant health issue affecting many people. The lab conducts studies using both human genetic data and mouse models to identify specific genes that influence alcohol sensitivity and tolerance. By exploring these genetic factors, the lab aims to uncover new prevention and treatment strategies for AUD.

Dr. Xinna Zhang's lab at Indiana University Indianapolis focuses on enhancing the immune response against colorectal cancer by improving how tumors present antigens to the immune system. The team investigates how herbal compounds can boost the effectiveness of cancer immunotherapies. They aim to develop innovative strategies to make colorectal tumors more recognizable to immune cells so that treatments can work better for patients.

Dr. Jungsu Kim's lab at Indiana University specializes in understanding the genetic factors that contribute to Alzheimer's disease, particularly focusing on the immune system's role in the disease's progression. By exploring the functions of specific genes in microglia, the brain's immune cells, the lab aims to uncover new therapeutic targets and improve our understanding of this complex disease. Students can expect to engage in cutting-edge research that combines molecular genetics, cellular biology, and advanced imaging techniques.

Dr. Bruce T. Lamb's lab focuses on understanding how genetic variations in the PLCG2 gene influence the biology of microglia, the immune cells of the brain, and contribute to Alzheimer's disease. By studying these variants in mouse models, the lab aims to elucidate their effects on disease progression and identify potential therapeutic targets. This research is crucial for developing new treatments for Alzheimer's disease.

Dr. Stephanie M. Ware leads a research lab focused on understanding the genetic basis of congenital heart disease and undiagnosed rare diseases. The lab explores how specific genes, like SHROOM3, contribute to heart malformations and uses a range of genomic techniques to identify patients at risk for rare genetic conditions. Their work aims to improve healthcare access and diagnostic methods for underserved populations in Indiana.

Dr. Kenneth White's lab focuses on understanding how aging affects muscle and bone health. They are particularly interested in the biochemical pathways that connect muscles, bones, and kidneys, and how these pathways can be influenced by factors like exercise. By investigating the role of specific molecules, such as L-BAIBA and FGF23, the lab aims to identify new therapeutic strategies to improve the quality of life for aging individuals who face issues like sarcopenia and osteoporosis.