Dr. Sean F. Brady's lab at Rockefeller University focuses on discovering new antibiotics from soil microbiomes using advanced metagenomic techniques. By extracting DNA directly from environmental samples, they bypass the need to culture bacteria, enabling the identification of a vast array of novel natural products. These new compounds may serve as lead structures for the development of effective therapies against drug-resistant bacterial pathogens.

Dr. Junyue Cao's research lab at Rockefeller University is focused on understanding how neurogenesis, or the generation of new neurons, changes in the aging brain and in conditions such as Alzheimer's disease. The lab employs advanced genomic techniques to investigate the complexities of these processes at the single-cell level, aiming to uncover potential therapeutic strategies to restore normal brain function. Through innovative high-throughput methodologies, the lab seeks to visualize and characterize the molecular dynamics of neuronal growth and differentiation across various conditions.

Dr. Jean-Laurent Casanova's lab at Rockefeller University focuses on understanding how genetic defects in immune responses can lead to diseases caused by infections, such as chronic mucocutaneous candidiasis and herpes simplex encephalitis. By exploring the genetic basis of these conditions, the lab aims to identify the underlying causes and improve treatment options for affected individuals, particularly in the context of life-threatening COVID-19. The research combines clinical aspects with advanced genomic techniques to shed light on human immunity.