Dr. Lena Al-Harthi's lab investigates the complex interplay between HIV and drug abuse, particularly focusing on how substances like methamphetamine affect cognitive health in individuals living with HIV. They utilize innovative humanized animal models to explore how HIV hides in the brain and how it impacts brain function and homeostasis. By studying these mechanisms, the lab aims to develop better strategies for addressing cognitive impairments in HIV-positive drug users.

Dr. Joao Filipe Inacio Mamede's lab studies HIV and its effects on the brain, particularly focusing on how HIV and substance abuse, like Methamphetamine, trigger neuroinflammation and cognitive disorders. They explore the cellular interactions and molecular pathways involved in these processes, aiming to uncover new therapeutic targets to improve the health of individuals living with HIV/AIDS. Through advanced techniques, the lab seeks to better understand brain responses in people who experience these conditions despite current treatments.

Dr. Xiu-Ti Hu's lab at Rush University focuses on understanding how HIV and cocaine use affect brain function, particularly in relation to neurocognitive disorders. The research aims to unravel the complex interactions between chronic HIV treatment and cocaine addiction, exploring their combined effects on neuronal health and cognitive abilities. By using animal models, the lab investigates the underlying mechanisms that contribute to neuronal dysfunction and seeks to identify new therapeutic strategies for improving cognitive outcomes in people living with HIV.

Dr. Jennillee Wallace's lab at Rush University Medical Center studies how HIV affects the brain, specifically looking at its impact on cognitive functions and inflammation. By using human-mouse chimera models, the lab investigates how HIV-infected immune cells infiltrate the brain and contribute to cognitive deficits. This research aims to deepen our understanding of neuroHIV, especially in individuals undergoing antiretroviral therapy.