Dr. Minji Byun's lab at UC Irvine focuses on understanding how mutations in the DNMT3A gene, particularly common in older adults, affect inflammation and increase the risk for diseases like cancer and heart disease. The lab uses advanced human cell models to explore the molecular mechanisms linking these mutations to altered immune responses. Their goal is to uncover insights that could lead to new treatments for diseases associated with DNMT3A mutations.

Dr. Yongsheng Shi's lab at UC Irvine focuses on understanding the processes that control how genes are expressed at the molecular level, particularly through mechanisms called alternative polyadenylation (APA) and alternative splicing. The research is particularly interested in how these processes affect B cell development and function, which are critical for the immune response. By uncovering the regulatory networks involved, the lab aims to provide insights that could lead to improved treatments for autoimmune diseases and cancer.

Dr. Anthony A. James' lab at UC Irvine focuses on developing innovative genetic strategies to combat malaria, a disease that significantly impacts global health. They are particularly interested in using gene-drive systems, which harness CRISPR technology, to alter the reproductive capabilities of malaria-carrying mosquitoes, thereby reducing their populations and spreading resistance to the malaria parasite. The lab's work aims to provide new tools that are effective, safe for humans and the environment, and resilient against reinvasion by susceptible mosquito populations.

Dr. Thomas P. Burke's lab focuses on understanding how Rickettsia, a type of tick-borne bacteria, evade the immune system. They are investigating how these bacteria survive inside immune cells and how they avoid detection by the body's defenses. This research could lead to new treatments and vaccines for serious diseases caused by Rickettsia, such as Rocky Mountain spotted fever.