Dr. Yun Lei's lab at Augusta University focuses on understanding how specific neurons in the brain, particularly in the entorhinal cortex, are affected by Alzheimer's disease (AD) as we age. The research investigates the role of epigenetic changes, particularly involving a protein called EZH2, in the loss of these neurons and cognitive decline associated with AD. By exploring these mechanisms, the lab aims to uncover potential therapeutic targets for preventing or mitigating AD-related neuronal damage.

Dr. David C. Hess's lab at Augusta University focuses on understanding how red blood cell dysfunction affects cognitive decline, particularly in conditions like vascular cognitive impairment and dementia. The team investigates whether improving red blood cell function through exercise and a conditioning technique can enhance brain health and potentially prevent cognitive issues in patients. Their research aims to uncover new therapeutic strategies targeting red blood cells to tackle dementia effectively.

Dr. Carlos M. Isales's lab is focused on understanding the biological processes involved in muscle and bone loss as we age. Through studying the effects of a substance called kynurenine, the lab aims to identify how aging impacts our body's ability to maintain muscle strength and bone density. This research is particularly important for preventing falls and fractures in the elderly, ultimately looking to enhance their quality of life.

Dr. Xin-Yun Lu's lab at Augusta University focuses on understanding the mechanisms of Alzheimer's disease (AD) and the effects of aging and chronic stress on brain health. The research investigates how specific neurons respond to stress and aging, and how inflammation in the brain can affect cognitive function over time. By exploring factors like HDAC9 and the Duffy Antigen Receptor for Chemokines (DARC), the lab aims to uncover therapeutic targets to help combat cognitive decline associated with Alzheimer’s disease.

Dr. Qin Wang's lab at Augusta University studies the relationship between brain cell signaling and neurodegenerative diseases, particularly Alzheimer's disease. They focus on how certain genes and signaling pathways that activate brain cells like astrocytes influence disease progression. Additionally, they explore how specific proteins regulate neuron activity, impacting emotional responses and behavior. Their work aims to uncover potential new therapeutic strategies for Alzheimer's and understanding stress-related mental health issues.