Dr. Shuiying Hu's lab at Ohio State University focuses on understanding how the chemotherapy drug vincristine causes damage to peripheral neurons and finding ways to prevent this neurotoxicity. The lab studies how vincristine is taken up by neurons through specific transporters and aims to develop drugs that can protect these neurons while still allowing vincristine to effectively target cancer cells. Their research could lead to safer cancer treatments with fewer side effects for patients.

Dr. Macarius M. Donneyong's lab at Ohio State University focuses on understanding the risks associated with using multiple medications (polypharmacy) in older adults, particularly those aged 65 and over. The lab aims to identify specific combinations of three drugs that could lead to serious adverse drug events (ADEs) like gastrointestinal bleeding, hypoglycemia, and opioid-related complications, which are common reasons for emergency department visits. By using advanced data mining and pharmacoepidemiological methods, the lab works to improve drug safety recommendations for older patients.