Dr. Yutong Zhao's lab at Ohio State University focuses on understanding the mechanisms of acute inflammatory diseases and idiopathic pulmonary fibrosis (IPF). The team investigates how specific proteins regulate cell metabolism, inflammation, and fibrosis in the lungs. By studying these processes, they aim to identify new therapeutic strategies to treat conditions like sepsis and lung injuries.

Dr. Xun Ai's lab at Ohio State University focuses on understanding the molecular mechanisms behind atrial fibrillation (AF), particularly how alcohol consumption and inflammation contribute to this common heart condition. The research aims to identify new therapeutic targets and biomarkers related to AF, especially in the context of postoperative scenarios and alcohol-induced heart damage. Through a combination of electrophysiological techniques and biochemical assays, the lab seeks to establish a novel understanding of the interactions between stress-response pathways and inflammation in AF pathogenesis.

Dr. Jing Zhao's lab at Ohio State University is focused on understanding how certain proteins regulate the immune response during severe bacterial infections. They study the role of a specialized protein complex called the immunoproteasome, particularly how it contributes to inflammation and tissue damage in conditions like pneumonia and sepsis. The goal is to identify new targets for therapies that can help control harmful inflammation and improve patient outcomes.

Dr. Harpreet Singh's lab at Ohio State University focuses on understanding the roles of specific potassium channels in heart and cell function, particularly in relation to exosomes and mitochondria. The team investigates how these channels can affect heart health, including preventing damage during conditions like ischemia. Their research may lead to new therapies for heart disease by exploring the potential of exosomal channels in drug delivery and cardiac protection.

Dr. Nuo Sun's lab focuses on understanding how mitochondrial health affects heart function as we age. They study processes called mitophagy and neddylation to see how the heart can maintain good mitochondrial quality and how these processes can be targeted for new treatments for heart diseases, particularly in regard to aging and metabolic changes. By using innovative mouse models and advanced genetic techniques, the lab aims to discover new insights into heart health and dysfunction.