Dr. Edward Harhaj's lab at Penn State University focuses on understanding how proteins regulate the immune system and mitochondrial health. Specifically, the lab investigates how the zinc finger protein ZFAND6 influences the removal of damaged mitochondria, and how the protein TAX1BP1 modulates inflammatory signaling pathways. This research aims to uncover mechanisms that could lead to new treatments for diseases associated with chronic inflammation and immune dysfunction.

Dr. Craig M Meyers' lab at Pennsylvania State University Hershey Medical Center studies the effects of HIV treatment on the progression of HPV-related oral cancers. They focus on understanding how highly active antiretroviral therapy (HAART) impacts cancer development and prognosis in patients with HIV and HPV co-infections. The lab uses innovative in vitro models to explore the mechanisms underlying these cancers and aims to identify potential therapeutic targets.

Dr. Shengyu Yang's lab at Pennsylvania State University focuses on understanding how mitochondrial calcium signals affect the spread and advancement of pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). They explore the molecular mechanisms behind cell migration and invasion in cancer, aiming to identify potential therapeutic targets to better treat this aggressive cancer. The research may lead to innovative approaches that could help prevent the recurrence of metastatic pancreatic cancer.

Dr. Nelli Mnatsakanyan's research lab focuses on understanding the role of mitochondrial dysfunction in Alzheimer's disease. They are particularly interested in a specific channel in mitochondria that may contribute to cell death. By using advanced imaging techniques, the lab aims to uncover the structural details of this channel and explore how blocking it could help protect neurons from damage caused by Alzheimer's. Their work could lead to new treatments for this devastating disease.

Dr. Joseph Che-Yen Wang's lab focuses on studying the Hepatitis B virus (HBV), which is a major global health issue affecting millions. The lab uses advanced imaging techniques, particularly cryo-electron microscopy, to explore the detailed structures of HBV capsids and virions as they develop in human cells. This research aims to uncover the mechanisms of viral replication and potential targets for new antiviral treatments.

Dr. Pingnian He's lab focuses on understanding how atherosclerosis, a common vascular disease, leads to cognitive impairments and dementia. With an aging population increasing the prevalence of these conditions, the lab investigates the specific mechanisms linking blood vessel health to brain function. By conducting experiments in animal models and human samples, the lab aims to uncover potential therapeutic targets and preventive strategies for cognitive decline.

Dr. Christopher Yengo's lab focuses on understanding how specific proteins, known as myosins, influence the shape and function of cells in both the inner ear and heart muscle. By studying myosins that control hair cell structures critical for hearing and those linked to heart conditions, the lab aims to uncover the underlying mechanisms of deafness and heart disease, which could lead to potential therapies.