Dr. Henry N Higgs' lab at Dartmouth College studies the dynamic interplay between the actin cytoskeleton and mitochondria in mammalian cells. The team focuses on understanding how transient actin structures influence mitochondrial function and energy metabolism, particularly in relation to diseases linked to dysfunctional mitochondria. Their research has significant implications for various cellular processes and could lead to insights in treating conditions such as Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis.

Dr. Charles L. Sentman's lab at Dartmouth College focuses on developing innovative therapies for Alzheimer's disease using genetically engineered immune cells. The lab's main project involves creating chimeric antigen receptor (CAR) T regulatory cells that can target and clear harmful amyloid-beta protein plaques in the brain, while reducing inflammation associated with the disease. By enhancing the persistence and activity of these targeted cells, the goal is to improve treatments for Alzheimer's and its neurodegenerative effects.

Dr. James B Bliska's lab at Dartmouth College studies how certain bacterial proteins can help pathogens avoid detection and destabilize the body's immune defenses. They focus on understanding how bacteria, like Yersinia, use specialized mechanisms to disrupt protective pathways in immune cells during infection. This research not only enhances our understanding of bacterial infections but also aims to inform new approaches to boost immune defenses against such pathogens.

Dr. Jennifer Melinda Bomberger's lab at Dartmouth College focuses on understanding the interactions between bacteria and viruses in the context of cystic fibrosis. By studying how Pseudomonas aeruginosa, a harmful bacterium, survives and causes disease in the lungs of cystic fibrosis patients, the lab aims to uncover mechanisms that promote bacterial persistence and chronic infections. Their work could lead to new therapeutic strategies to combat these severe infections.

Dr. Pamela Rosato's lab at Dartmouth College focuses on studying the role of brain resident T cells in Alzheimer's Disease. The lab investigates how these immune cells, particularly a type called CD8+ tissue resident memory T cells, influence disease progression and cognitive decline. By combining mouse models with human tissue analysis, the lab aims to uncover novel therapeutic targets and improve our understanding of neuroinflammation in Alzheimer's and potentially other neurological disorders.

Dr. Keith D. Paulsen's research lab focuses on improving breast cancer diagnosis through innovative imaging techniques. By combining near-infrared spectroscopic tomography (NIRST) with magnetic resonance imaging (MRI), the team seeks to create a diagnostic tool that does not require contrast injection or ionizing radiation. Their work aims to enhance the detection capabilities for breast abnormalities and contribute to better clinical management for patients.

Dr. James B Moseley's lab at Dartmouth College studies how cells control their size and shape, focusing on basic cellular mechanisms that can contribute to diseases like cancer. By using fission yeast as a model organism, the lab explores the processes involved in cell growth and division. Their interdisciplinary approach combines genetics and various microscopy techniques to uncover important signals that regulate these fundamental biological functions.

Dr. Joshua J. Obar's lab focuses on understanding how the fungus Aspergillus fumigatus causes chronic lung diseases such as allergic bronchopulmonary aspergillosis (ABPA), particularly in patients with cystic fibrosis. The lab investigates the interactions between this fungus and the immune system, specifically looking at how certain immune cells called alveolar macrophages can either help or hinder the persistence of the fungus in the lungs. This research aims to reveal new ways to treat chronic fungal infections by targeting these immune cells to improve health outcomes for patients.

Dr. Robert Cramer's lab at Dartmouth College focuses on understanding and overcoming fungal infections, particularly those caused by the mold Aspergillus fumigatus, which can be deadly for immunocompromised patients. The lab develops new antifungal drugs that are effective against drug-resistant strains of moulds and studies how certain cancer therapies can influence fungal pathogenicity. They combine chemical biology, genetic analysis, and mouse models to tackle these pressing health issues.

James Haxby's research lab at Dartmouth College focuses on improving the analysis and sharing of functional brain imaging data using a method called hyperalignment. This technique helps resolve differences in brain activity patterns among individuals, allowing for better understanding of how various cognitive functions are represented in different brains. The lab aims to create a common platform for researchers in neuroscience to access and contribute valuable data, improving research on brain aging, cognitive processes, and clinical applications.

Dr. Shudong Jiang's lab at Dartmouth College focuses on developing innovative imaging technologies to improve the early detection of breast cancer treatment responses. They are particularly interested in using Near-infrared Spectral Tomography (NIRST) to monitor vascular changes in breast tumors during neoadjuvant chemotherapy. This research could offer a noninvasive and cost-effective way to predict the effectiveness of cancer treatments much earlier than traditional methods.

In Fredrick Jon Kull's lab at Dartmouth College, researchers study how certain bacteria can cause disease and how they can be inhibited. They focus on a group of proteins that regulate virulence genes in bacteria, which are vital for pathogenicity. By understanding these proteins' structure and function, the lab aims to discover new ways to combat bacterial infections.

Dr. Claudia V Jakubzick leads a research lab at Dartmouth College that focuses on understanding the role of mononuclear phagocytes in the immune system. Her lab compares the function and gene expression of these immune cells in both humans and mice to identify their similarities and differences. This work aims to improve our understanding of how these cells respond to infections and how this knowledge can be applied to develop better treatments for diseases.

Dr. Tor D. Wager's lab at Dartmouth College focuses on understanding how placebo treatments can lead to real changes in brain activity and improve mental health outcomes. The lab investigates the neuroscientific mechanisms behind placebo effects, emphasizing the role of interpersonal interactions and mental states. Their research aims to bridge the gap between placebo studies and clinical applications in psychological and neurological treatments.

Dr. Surachai Supattapone's lab at Dartmouth College focuses on understanding prion diseases, which are caused by misfolded proteins that lead to neurodegenerative disorders such as Creutzfeldt-Jakob disease. The lab uses advanced genetic screening techniques to map the molecular pathways that control the metabolism of prion proteins, aiming to identify potential new targets for drug therapy. Their research not only enhances our knowledge of prion biology but also contributes to the development of therapeutic strategies for these fatal brain diseases.

Dr. Margaret E Ackerman's lab at Dartmouth College focuses on novel antibody therapies to combat viral infections, specifically HIV and neonatal herpes simplex virus (nHSV). They explore how broadly neutralizing antibodies (bNAbs) can be engineered and optimized to enhance their effectiveness in preventing these infections. The research aims to translate these approaches into practical treatments that can significantly improve health outcomes for affected populations.

Professor Geoffrey P. Luke's lab at Dartmouth College focuses on developing advanced imaging techniques to improve cancer detection, specifically for head and neck cancers. The lab aims to create a non-invasive ultrasound imaging tool that uses special contrast agents to identify small cancerous deposits in lymph nodes. By improving detection methods, the research hopes to enhance treatment planning and ultimately improve patient outcomes.

Dr. Yina Hsing Huang's research lab focuses on understanding how certain immune cells, particularly tissue-resident memory T cells, can be sustained and made effective against cancer. The lab investigates innovative strategies for enhancing chimeric antigen receptor (CAR) T cell therapies, which show promise in treating solid tumors by overcoming the immune suppression created by the tumor environment. Their work aims to develop better long-lasting immune responses that can protect individuals from cancer recurrence.

Dr. Periannan Kuppusamy's lab at Dartmouth College is focused on developing innovative medical devices to improve cancer treatment. The primary project involves creating a specialized scanner that can measure the oxygen levels in tumors in real-time, which can help in planning better radiation therapy. This research combines engineering with clinical applications to enhance cancer care and monitor important health indicators.

Dr. Mary Jo Turk's lab at Dartmouth College focuses on understanding how a specific type of immune cell, called tissue resident memory T cells, functions in fighting cancer. Their research looks at how these cells are generated, how they move within the body, and their role in preventing cancer recurrence and spread. By studying both mice and human patients, the lab aims to develop strategies to enhance tumor immunity, potentially leading to better cancer treatments.