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Xuexian Yang — Dr. Xuexian Yang's laboratory focuses on understanding allergic airway inflammation, which is a significant health issue affecting many people. The lab investigates the role of a specific group of immune cells, known as group 2 innate lymphoid cells (ILC2s), in the development of allergic responses and asthma. By studying how these cells are regulated, the lab aims to uncover new strategies for treating allergic asthma and improving patient outcomes.
Michelle A Ozbun — Dr. Michelle Ozbun's lab focuses on understanding how human papillomaviruses (HPVs) contribute to tumor development and regression, particularly through the inhibition of cellular signaling pathways. The lab investigates how MEK inhibitors can suppress HPV-related tumors and promote the immune response to fight these infections. Their work could lead to new treatments for HPV-associated diseases that currently have limited options.
Matthew J Campen — Dr. Matthew J Campen's lab focuses on understanding how exposure to wildfire smoke and metals contamination affects brain and vascular health, particularly from an aging perspective. The research aims to uncover the links between environmental pollutants and neuroinflammation, and how these factors may contribute to neurodegenerative diseases such as Alzheimer's. The lab employs both field studies and laboratory experiments to analyze the health impacts of contaminated wood smoke and seeks potential therapeutic interventions.
Carlos Fernando Valenzuela — Dr. Carlos Fernando Valenzuela's lab focuses on understanding how fetal alcohol exposure affects brain development and cognitive function. The research aims to identify the specific mechanisms behind the cognitive deficits caused by fetal alcohol spectrum disorders (FASDs), using advanced techniques like electrophysiology in animal models. Ultimately, the lab seeks to develop targeted treatments to improve outcomes for individuals affected by FASDs.
Kimberly K. Leslie — Dr. Kimberly K. Leslie's lab focuses on improving hormone therapy for endometrial cancer, which has been an area of limited progress over the last several decades. The research aims to identify and evaluate better progestin treatments to prevent and manage endometrial cancer, as well as to minimize the risks associated with these therapies, particularly breast cancer. They seek to enhance clinical outcomes for patients by systematically studying the effectiveness of different progestins and understanding how patients can benefit most from these treatments.
Vallabh O Shah — Dr. Vallabh Shah's lab focuses on improving the health and well-being of Zuni elders through fall prevention strategies. By adapting traditional physical therapy programs to meet the cultural needs of Native elders, the lab aims to empower this community to reduce the risks associated with falls and support aging in place. This research not only addresses health disparities but also fosters collaboration and cultural understanding between the Zuni Pueblo and health services.
Si-Ming Zhang — Dr. Si-Ming Zhang's lab studies how certain freshwater snails resist schistosomiasis-causing parasites. By exploring the genetics and genomics of these snails, the lab aims to identify resistance mechanisms and develop new strategies for controlling the transmission of schistosomiasis—a disease that affects millions of people worldwide. This research could pave the way for innovative methods to block the lifecycle of these harmful parasites.
Thomas C Resta — Dr. Thomas C. Resta's lab focuses on understanding how chronic hypoxia affects vascular health, specifically in the context of pulmonary hypertension. The research examines the role of oxidative signaling mechanisms that change how cells in the lungs respond to various stimuli. By investigating how changes in cholesterol and reactive oxygen species contribute to vascular dysfunction, the lab aims to uncover new treatment strategies for chronic lung diseases.
Ludmila Nicole Bakhireva — Dr. Ludmila Bakhireva's lab focuses on understanding how early life exposures shape child development. Through the Healthy Brain and Child Development (HBCD) Study, they are tracking a diverse group of 7200 mothers and infants to identify the impacts of various environmental factors, such as substance exposure during pregnancy. By using advanced brain imaging and extensive behavioral assessments, they aim to create a comprehensive understanding of neurodevelopmental trajectories during the first decade of life to inform public health policies.