Dr. Marc Tatar's lab at Brown University explores how aging affects the communication between the kidney, adrenal glands, and heart. They focus on understanding a condition known as cardiorenal syndrome, where dysfunction in one organ can lead to problems in others, particularly in older adults. Through transplant experiments in mice, the lab examines how these interactions may promote fibrosis and contribute to age-related organ decline.

Dr. Thomas Benedict Bartnikas's lab at Brown University focuses on understanding how the body balances iron and manganese levels, which are necessary for health but can be toxic in excess. The lab investigates how inherited conditions, such as hereditary hemochromatosis, affect the regulation and absorption of these metals. Their research helps to uncover the fundamental processes that maintain the balance of important nutrients while preventing toxicity.

Dr. Jonathan D. Kurtis leads a research lab focused on developing new treatments for severe malaria, specifically targeting a protein called PfGARP found on the surface of malaria-infected red blood cells. The lab's work aims to create a novel class of antimalarial drugs that could effectively combat the rising issue of drug resistance in Plasmodium falciparum, the parasite responsible for malaria. Through high-throughput drug screening and testing in humanized mouse models, the lab seeks to discover and refine new drugs to improve health outcomes in affected populations.

Dr. Sean Edward Lawler's lab at Brown University focuses on understanding how cytomegalovirus (CMV) influences glioblastoma, a type of aggressive brain cancer. By using a special mouse model where the virus is present, the lab aims to uncover the interactions between CMV and tumor growth, which could lead to new treatments for patients. The research highlights the potential of CMV as a therapeutic target and seeks to improve therapy effectiveness in glioblastoma patients.