Dr. Ali H. Brivanlou's lab focuses on using marmoset monkeys to study Huntington's disease, a complex neurodegenerative disorder that affects movement and cognition. The lab aims to create genetic models that mirror human conditions by employing advanced techniques like CRISPR and stem cell technologies. By understanding the molecular basis of Huntington's disease in a primate context, the research seeks to uncover new insights into its causes and how it might be treated.

Dr. Elaine Fuchs' lab at Rockefeller University studies how skin stem cells contribute to tissue growth, maintenance, and healing. The research focuses on understanding how these cells communicate with their environment and respond to signals, which is crucial for maintaining healthy skin and informing regenerative medicine. By investigating the mechanisms of stem cell behavior and their role in diseases like cancer, the lab aims to develop new therapeutic strategies for skin-related disorders.

Dr. Hironori Funabiki's lab at Rockefeller University focuses on understanding how chromosomes are inherited and maintained during cell division, processes that are crucial for preventing diseases like cancer. The lab utilizes innovative techniques involving Xenopus egg extracts to study the structure and regulation of nucleosomes, which are essential for the integrity of our genetic material. Through their research, they aim to uncover the roles of specific proteins in maintaining chromosome stability and preventing immune responses that could lead to cell death.

Dr. John Lacava's research lab focuses on understanding the role of LINE-1 retrotransposons in neurodegenerative diseases like Alzheimer's Disease and related dementias. By investigating how these genetic elements contribute to cellular aging and inflammation, the lab aims to uncover potential mechanisms behind the onset of these diseases. Through various experimental approaches, including examining biological samples from patients and cell cultures, the lab seeks to clarify the relationship between LINE-1 and cellular senescence, ultimately hoping to inform strategies for better understanding and treating these conditions.

Dr. Sidney Strickland's lab at Rockefeller University focuses on understanding the mechanisms of Alzheimer's disease (AD), particularly the roles of inflammation and blood clotting. They investigate how interactions between the beta-amyloid peptide and fibrinogen contribute to cognitive decline and vascular dysfunction in AD. The lab aims to develop new therapeutic strategies by targeting these molecular interactions and understanding their impact on brain health.

Dr. Sohail F. Tavazoie's lab at Rockefeller University focuses on understanding the biology and genetics behind the process of metastasis, which is how cancer spreads from its original site to other parts of the body. By examining how certain genetic variants and microRNAs influence metastasis, the lab aims to identify critical pathways that could lead to new therapies for cancer. Their work has significant implications for developing targeted treatments that can prevent or reduce metastasis in various cancers.

Dr. Titia De Lange's lab at Rockefeller University studies how telomeres—the protective caps at the ends of chromosomes—affect cancer and cellular aging. They investigate the mechanisms behind genome instability in tumors caused by telomere shortening, and how this can lead to issues such as replicative senescence, which limits cell proliferation. Their research aims to provide insights that could potentially inform cancer treatments and preventive strategies.

Michael P Rout's lab at Rockefeller University focuses on innovative solutions to combat viral pandemics and understand important cellular structures called nuclear pore complexes. They develop advanced nanobodies from llamas to neutralize and treat infections caused by dangerous viruses like SARS-CoV-2, enhancing our preparedness for future outbreaks. Additionally, the lab investigates the structure and function of nuclear pore complexes to better understand their critical roles in gene regulation and cell function, aiming to uncover potential therapeutic targets for various diseases.