Dr. Yigang Wang's lab focuses on understanding heart failure, a serious condition affecting millions globally. They explore how specific molecules, called miRNAs, impact heart cells and contribute to heart disease. By studying the mechanisms behind these processes, the lab aims to develop innovative therapies to mitigate heart failure and improve patient outcomes.

Dr. Maria Czyzyk-Krzeska's lab focuses on understanding the role of copper metabolism in clear cell renal cell carcinoma (ccRCC), a common and aggressive type of kidney cancer. By investigating how copper accumulation affects tumor growth and metabolism, the lab aims to identify new therapeutic strategies and biomarkers to improve treatment outcomes for patients. Their research combines cell line models and patient-derived tumor grafts to uncover critical mechanisms in cancer progression.

Dr. W Sean Davidson's lab at the University of Cincinnati focuses on understanding high-density lipoproteins (HDLs), often referred to as 'good cholesterol.' The lab aims to explore how different HDL forms function in protecting against heart disease and diabetes. Through a combination of laboratory experiments and computational modeling, the team investigates the molecular mechanisms of cholesterol transport and the role of specific HDL particles in cardiovascular health.

Dr. Yu Luo's lab at the University of Cincinnati focuses on understanding how specific signaling pathways in the brain, particularly those involving microglia and astrocytes, affect brain health and diseases like stroke and Alzheimer's. The research aims to uncover the roles of the TGF-beta signaling pathway in maintaining healthy brain cells and to explore how the choroid plexus and cerebrospinal fluid contribute to cognitive function, especially during aging and in neurodegenerative conditions.

Dr. Eric S Wohleb's lab at the University of Cincinnati investigates how chronic stress impacts the brain, particularly focusing on how stress causes changes in neurons that can lead to mental health disorders like PTSD and depression. The research looks at DNA damage in stressed neurons and how it alters gene activity and neuron structure. By understanding these processes, the lab aims to find new ways to treat stress-related cognitive issues.

Dr. Nalinikanth Kotagiri's lab focuses on innovative imaging techniques to improve the diagnosis and treatment of lung infections, particularly in patients with chronic obstructive pulmonary disease (COPD). The research involves developing specialized imaging probes that can identify specific bacteria causing infections, which are crucial for targeted therapies. By using cutting-edge imaging technologies, the lab aims to differentiate between bacterial and viral infections, thereby enhancing treatment outcomes and patient management.