Dr. Joseph Y Lo's research lab at Duke University focuses on improving how radiologists analyze complex body CT scans using advanced artificial intelligence (AI) tools. The lab is working on creating a computer-aided diagnosis triage tool that helps radiologists prioritize scans with actionable diseases. By leveraging large datasets and innovative deep learning techniques, the lab aims to enhance diagnostic performance and streamline workflow in medical imaging, ultimately benefiting patient care.

Dr. Lars J. Grimm's research lab focuses on improving breast cancer screening processes, particularly how to better interpret mammographic calcifications. The team aims to distinguish between benign and malignant conditions through innovative imaging and biomarker analysis over time. By leveraging data from multiple mammograms and tissue samples, their goal is to reduce unnecessary biopsies and overtreatment of patients diagnosed with early-stage breast cancer.

Cristian T Badea's lab at Duke University focuses on advancing cancer treatment and non-invasive imaging techniques. They develop innovative platforms to improve the understanding of complex tumors, particularly in head and neck cancers, while also enhancing the detection of aneurysms in the brain using advanced imaging technologies. Their research aims to combine imaging innovations with therapy optimization to enable personalized medicine.

Dr. Joel Collier's lab at Duke University focuses on developing new types of treatments for chronic inflammatory diseases like inflammatory bowel disease and rheumatoid arthritis. Instead of using traditional antibody therapies that may not work for all patients, the lab designs innovative biomaterials that help the body's immune system generate its own healing responses. This involves creating smart materials that can help reduce inflammation and improve overall health outcomes with less frequent treatments.

Dr. Bastiaan Driehuys' lab focuses on developing advanced MRI technologies to improve the early detection and diagnosis of lung function issues, particularly related to dyspnea (shortness of breath). Their innovative approach uses hyperpolarized xenon MRI to visualize how well lungs exchange gases, providing detailed insights for better clinical decision-making. The lab aims to create a quick and comprehensive MRI exam that assesses multiple causes of breathlessness, particularly in patients affected by conditions like long COVID.

Dr. Jessilyn P Dunn's lab at Duke University focuses on innovative ways to detect prediabetes and type 2 diabetes early in adults using mobile technologies. The research aims to utilize data from everyday smart devices like smartphones and smartwatches to improve current screening methods. This lab develops wearable technologies that help monitor glucose levels and assess diabetes risk, benefiting the many people who are unaware of their diabetic conditions.

Dr. Sina Farsiu's lab focuses on understanding glaucoma, a major cause of blindness, by investigating how the eye's drainage system functions. They aim to develop advanced imaging technologies to observe and analyze changes in the anatomy of this system over time and in response to different treatments. The ultimate goal is to improve early diagnosis and personalize therapies for patients with glaucoma.

Dr. Charles A. Gersbach's lab at Duke University focuses on harnessing the immune system to enhance cancer treatments, particularly through adoptive T cell therapy. They use cutting-edge techniques to understand how to improve T cell function by manipulating specific genes and regulatory elements. The lab aims to make advancements in epigenetic engineering to create more effective cancer therapies and to systematically study gene regulatory elements that can impact diverse biological processes.

Ophelia Venturelli's lab at Duke University focuses on how dietary fibers influence the gut microbiome and the colonization of multi-drug resistant organisms (MDROs) in humans. Through innovative methods including human studies and computational modeling, the research aims to uncover the mechanisms by which diet affects microbial dynamics and health. Ultimately, the lab seeks to develop strategies that can reduce MDRO infections.

Dr. Sharon Gerecht's lab at Duke University focuses on creating advanced 3D models of the inner blood-retina barrier, which is crucial for understanding retinal diseases like diabetic retinopathy. By engineering these models with human retinal cells, the lab aims to mimic the environment of healthy retinal tissue and investigate how vascular dysfunction occurs. This innovative research provides insights into the mechanisms of retinal health and disease, which could lead to better treatments.

Dr. Junjie Yao's research focuses on improving treatments for urinary stone disease using advanced imaging techniques. His work aims to develop a new technology that can visualize cavitation bubbles during laser treatments in real-time, which could lead to more effective and safer procedures. By enhancing our understanding of how these bubbles contribute to stone fragmentation, the lab hopes to optimize laser lithotripsy techniques, ultimately benefiting patients suffering from this common condition.

Dr. Warren Grill's lab at Duke University focuses on developing advanced electrical methods to block nerve conduction, especially targeting small nerve fibers involved in pain and autonomic dysfunction. The research aims to optimize electrical waveforms and electrode designs to improve the precision and efficiency of nerve block techniques for clinical applications. This work has potential implications for treating conditions like diabetes, heart failure, and chronic pain management.

Dr. Cameron McIntyre's lab at Duke University focuses on understanding how brain stimulation therapies work by analyzing data and creating computational models. The lab explores the electrical signals recorded from the brain and the effects of stimulating certain areas, aiming to enhance neuromodulation therapies for clinical applications. They use advanced technologies like holographic visualization to support surgical planning for patients receiving deep brain stimulation.

Dr. Chang-Lung Lee's lab at Duke University focuses on understanding how radiation therapy affects tissues, particularly in the context of head and neck cancer. One of their main projects aims to reduce the harmful side effects of radiation on oral tissue, specifically oral mucositis, by exploring the protective role of the p53 protein. The lab also investigates potential biomarkers for heart disease that could emerge following radiation exposure, which is crucial for identifying at-risk individuals after nuclear incidents.

The lab of Dr. Nirmala Ramanujam at Duke University focuses on developing innovative imaging technologies to study cellular metabolism and its relation to cancer therapy. Their flagship project is the CapCell Scope, which allows researchers to non-invasively observe metabolic changes and vascular characteristics in tissues. This research aims to enhance our understanding of how tumors respond to treatments, potentially leading to personalized cancer therapies.

Dr. Amanda E. Randles' research lab at Duke University focuses on creating advanced models of the cardiovascular system that can predict how individual patients will respond to various treatments over extended periods of time. By integrating machine learning with physics-based simulations, the lab aims to utilize real-time data from wearable sensors to enhance personalized medicine for cardiovascular diseases. Their innovative approach seeks to improve monitoring and treatment planning for patients, moving beyond short-term simulations to provide long-term, individualized hemodynamic insights.

Dr. Nenad Bursac's lab focuses on developing advanced engineered human skeletal muscle tissues to better understand and study muscle regeneration and the role of muscle stem cells. By creating complex 3D tissue models that mimic the natural environment of muscle stem cells, the lab aims to explore how different cell types interact and how these interactions affect muscle health and recovery. This research has significant implications for treating diseases like muscular dystrophies and improving muscle repair mechanisms.

Dr. Marc A. Sommer's lab at Duke University focuses on improving methods to manipulate neurons in the primate brain using light-sensitive proteins called opsins. They are specifically addressing challenges in delivering these proteins effectively with viral vectors, which can face issues due to the primate immune response. Through this research, the lab aims to enhance our understanding of visual and motor systems in the brain and improve gene therapy techniques that may also translate to human applications.

Dr. Pengfei Song's lab focuses on advancing ultrasound imaging technology, specifically developing a novel clip-on device that transforms standard 2D ultrasound systems into functional 3D imaging devices. This technology aims to make 3D ultrasound imaging more accessible and efficient for clinical applications, particularly in diagnosing conditions like breast cancer. The research integrates ultrasound innovation with medical device design to improve patient care.

Dr. Michael R. Tadross's lab at Duke University focuses on advancing neuropharmacology to improve treatments for neuropsychiatric disorders. The lab is developing an innovative technology called DART, which allows for precise drug delivery to specific types of brain cells in a noninvasive way. By understanding and targeting the cellular mechanisms of behavior, the team aims to transform how we study brain disorders and enhance treatment options for patients.