Dr. Mats Ljungman’s lab at the University of Michigan focuses on developing innovative cancer therapies using CRISPR technology, specifically targeting bladder cancer cells. The lab's research aims to precisely induce DNA damage in cancer cells by using a split CRISPR enzyme approach that minimizes effects on normal cells. Their goal is to advance this technique towards clinical trials, providing a new avenue for effective treatments for bladder cancer.

Dr. Nicolaas Ida Bohnen's lab focuses on how the brain's cholinergic system affects balance and movement in individuals with Parkinson's disease and older adults. The team investigates how changes in specific brain regions influence postural control and the risk of falls. By studying these relationships, the lab aims to uncover potential new strategies for preventing balance disorders associated with aging and neurological diseases.

Dr. Yuni K Dewaraja's research lab at the University of Michigan focuses on improving radioligand therapy for prostate cancer. The lab aims to make cancer treatment more personalized by developing methods to calculate the optimal dosage of radiation based on each patient's unique characteristics and response to therapy. By utilizing advanced imaging and modeling techniques, the research seeks to enhance treatment efficacy and reduce side effects for patients.

Dr. Anne Watson Draelos’s lab focuses on understanding the factors that contribute to cognitive resilience in Alzheimer’s disease through innovative machine learning techniques. By analyzing various types of biological and environmental data, the lab aims to uncover dynamics that influence how individuals age cognitively and how this knowledge can lead to new therapeutic strategies. The research integrates complex models to not only identify key factors but also test interventions based on predicted results, making the process of validating hypotheses faster and more efficient.

Dr. Xudong Fan's lab focuses on developing innovative diagnostic devices that analyze biological markers from breath and skin odors to detect and monitor various diseases. By utilizing micro-gas chromatography and machine learning, the lab aims to create portable devices for point-of-care use, enhancing diagnosis and patient monitoring for conditions like acute respiratory distress syndrome and skin diseases. Their work combines biomedical engineering, data science, and clinical expertise to significantly improve healthcare outcomes.

Dr. Daniel R Wahl's lab at the University of Michigan focuses on understanding and targeting the unique metabolism of glioblastoma, an aggressive form of brain cancer. The lab aims to develop innovative methods to measure metabolic activity in tumors, which can help doctors identify the best treatment strategies. By exploring how glioblastoma cells adapt their metabolism to resist treatments like radiation, the lab hopes to improve patient outcomes and discover new therapeutic approaches.

Timothy L. Hall's lab at the University of Michigan focuses on improving a cutting-edge method known as histotripsy, which uses high-intensity ultrasound to non-invasively destroy tissue, such as tumors in the liver. The lab aims to enhance this technique by developing advanced imaging and correction methods that ensure the treatment can be safely applied to a broader patient population. Their research could pave the way for more effective and precise medical treatments without the need for invasive surgery.

Dr. Jiahe Li's lab focuses on developing innovative microbial-based treatments for colorectal cancer, specifically targeting harmful metabolites produced by gut bacteria. They aim to understand how engineered non-pathogenic bacteria can neutralize a carcinogenic substance called colibactin, which is linked to cancer progression. The research combines microbiology with cancer biology to explore new therapeutic strategies for combating this disease.

Dr. Dariya Malyarenko's lab at the University of Michigan focuses on enhancing the accuracy of MRI diffusion imaging in oncology. The team develops correction tools to address biases in diffusion metrics caused by different MRI scanner designs, improving the reliability of cancer diagnosis and treatment assessments. Their work supports multi-center clinical trials, ensuring consistent and precise data across various medical imaging platforms, which is critical for effective cancer management.

Dr. Brian D. Ross leads a research lab focused on improving the diagnosis and treatment of myelofibrosis, a serious blood cancer. The lab is developing advanced MRI techniques to create noninvasive biomarkers that can better monitor the disease and evaluate the effectiveness of new targeted therapies. By integrating innovative imaging methods with cutting-edge treatment strategies, they aim to enhance patient management and outcomes for those suffering from this chronic illness.

Dr. Deepak Nagrath's research lab at the University of Michigan investigates how pancreatic cancer interacts with its surrounding environment to influence tumor growth and progression. The lab aims to understand the unique role of stromal cells in supporting cancer metabolism, particularly focusing on branched chain amino acids. By exploring these interactions, they hope to uncover new therapeutic strategies for treating pancreatic cancer.

Dr. Geeta Mehta's lab focuses on understanding the early stages of ovarian cancer, specifically how mutated cells from the fallopian tubes migrate and form tumors. The lab uses innovative microfluidic devices and bioreactors to mimic the fluid environment around these cells, allowing them to study how fluid shear stress affects cell behavior, replication, and potential tumor formation. Their research aims to uncover new insights that could lead to better detection methods and therapies for ovarian cancer.

Dr. Ariella Shikanov's lab focuses on developing innovative therapies to restore ovarian function in young women who suffer premature ovarian insufficiency, often due to cancer treatments. The research aims to enhance the delivery of cell-based therapies using immunoisolating capsules to prevent immune rejection. This work seeks to test the efficacy of these therapies in non-human primate models, paving the way for future clinical applications.

Dr. Chuan Zhou's research focuses on improving the treatment outcomes for patients with multiple myeloma, a type of blood cancer. His lab is developing a decision support system that combines MRI imaging with clinical data to enhance the prediction of how patients will respond to treatment. By using advanced artificial intelligence methods, the goal is to provide personalized treatment recommendations that can lead to better patient care and outcomes, ultimately working towards precision medicine in oncology.

Dr. Yun Jiang's lab focuses on improving how we detect and characterize prostate cancer using advanced magnetic resonance imaging (MRI) techniques. The lab is developing a rapid and objective method that allows doctors to easily differentiate between clinically significant and less severe forms of prostate cancer. By innovating MRI protocols, this research aims to reduce unnecessary biopsies and improve treatment decisions for patients diagnosed with prostate cancer.

Dr. Lonnie D. Shea's lab at the University of Michigan focuses on advanced biomedical engineering techniques to tackle major health issues like type 1 diabetes and breast cancer. The research includes developing improved pancreatic organoids and engineered scaffolds to enhance the effectiveness of cell transplants and monitor cancer progression. They aim to use innovative materials, such as nanoparticles and 3D scaffolding technologies, to improve therapeutic responses and patient outcomes.

Dr. Zhongming Liu's research lab focuses on understanding how the brain and stomach communicate with each other, especially in relation to feelings and digestion. By studying the intricate neural circuits that connect these two systems, the lab aims to map their interactions and how they affect overall health and well-being. This research could lead to better treatments for various mental and digestive disorders.

Dr. Janggun Jo’s lab focuses on developing advanced imaging technologies to improve the diagnosis of prostate cancer. By utilizing innovative photoacoustic imaging techniques combined with specialized nanoscale probes, the lab seeks to enhance the sensitivity and accuracy of cancer detection, specifically targeting the aggressiveness of tumors. Their research aims to create a platform that could ultimately improve clinical procedures for prostate cancer diagnosis, ensuring better outcomes for patients.

Dr. Zhen Xu's lab at the University of Michigan focuses on innovative ways to treat soft tissue sarcomas, which are challenging tumors to manage due to their size and location near critical structures. They are developing a new ultrasound-based system that can safely and effectively destroy these tumors without the need for surgery. This research aims to enhance patient outcomes by creating non-invasive treatment options that can potentially benefit both humans and animals.

Dr. Mitra Aliabouzar's lab focuses on developing advanced imaging techniques to better understand thrombus (blood clot) characteristics over time. By using ultrasound-responsive nanodroplets, the lab aims to create a non-invasive method that can provide real-time information about thrombus age and mechanical properties, enhancing treatment strategies for conditions like cardiovascular disease. This innovative approach has the potential to significantly improve patient outcomes by enabling timely and tailored treatments for thrombus-related complications.