Dr. Olivier Lichtarge's lab at Baylor College of Medicine focuses on understanding Alzheimer's Disease by exploring genetic factors and how they differ between men and women. The lab uses advanced computational methods to analyze genetic data, aiming to identify key genes that contribute to the risk of Alzheimer's. Through experimental validation in model organisms, the lab works to improve and tailor strategies for early detection and treatment of Alzheimer's Disease based on genetic insights.

Dr. Hui Zheng's lab at Baylor College of Medicine focuses on understanding the biological mechanisms behind Alzheimer's Disease (AD), particularly the roles of lipid metabolism and immune response in the brain. Researchers investigate how certain enzymes and pathways affect neuroinflammation and cognitive decline in AD. The lab's work aims to identify potential therapeutic targets to improve treatment options for Alzheimer's patients.

Dr. Lilei Zhang's lab at Baylor College of Medicine focuses on understanding genetic variations in the MYH7 gene, which are linked to heart diseases. The lab develops innovative methods for interpreting and validating these genetic variants using advanced technologies like single cell RNA sequencing and machine learning. This research aims to improve the diagnosis and treatment of cardiomyopathies and other hereditary conditions by providing deeper insights into how gene mutations affect heart cell function.

Brendan Lee's lab at Baylor College of Medicine focuses on understanding the genetic and cellular basis of disease to improve diagnostics and treatment options, particularly for newborns and patients with complex skeletal conditions. The lab is leading innovative projects that use advanced technologies like genomic sequencing and neuroanatomical mapping to enhance medical care in underserved areas. Through their research, they aim to reduce health disparities and develop new therapeutic strategies for various conditions, including osteoarthritis and Osteogenesis Imperfecta.

Dr. Benjamin Arenkiel's lab focuses on understanding how specific brain circuits govern body weight control and feeding behavior. They explore the role of cholinergic signaling in the brain, particularly looking at how these signals affect regions involved in appetite regulation. By uncovering these mechanisms, the lab aims to provide insights into obesity and related metabolic disorders, which are significant health issues today.

Dr. Graham Scott Erwin's lab at Baylor College of Medicine focuses on developing innovative tools for genomic medicine. They are creating new classes of small, cell-permeable molecules to edit specific DNA sequences, addressing challenges in treating genetic disorders, especially those involving repetitive DNA. By rationally designing these genome regulators, the lab aims to enhance precision medicine and make new therapeutic strategies accessible to researchers.

Dr. Elizabeth Grace Atkinson's lab at Baylor College of Medicine focuses on improving methods for genetic analysis of individuals with mixed ancestral backgrounds. The goal is to develop innovative statistical techniques and software to aid in gene discovery and clinical applications, making genetic research more inclusive and accurate for diverse populations. Their work will create open-access tools that can be utilized in both research and clinical settings, improving the understanding of genetics across admixed populations.

Dr. Hugo J. Bellen's lab focuses on using genomic medicine to help underserved populations, particularly those unable to afford DNA testing for rare diseases. The research team combines expertise from various fields to identify and study new disease genes, utilizing advanced techniques like whole-exome sequencing and model organisms like fruit flies. The ultimate goal is to improve diagnostics and care for individuals with rare genetic disorders while also contributing to broader genomic knowledge.

The lab led by Richard A. Gibbs at Baylor College of Medicine focuses on understanding genetic variations that contribute to various rare diseases. Through advanced genomic sequencing techniques and a large-scale network of collaborations, the lab enrolls families with difficult-to-diagnose conditions and aims to uncover the genetic causes behind these issues. By utilizing cutting-edge technology and rigorous data analysis, the lab works not only on individual cases but also on population-scale genomic studies to enhance diagnosis and treatment strategies.

Dr. Jason D. Heaney's lab at Baylor College of Medicine focuses on producing and studying genetically modified mice to understand gene function and its implications for human disease. By creating mouse models with specific gene knockouts, the team conducts comprehensive phenotyping to gather data on gene roles in various biological processes. This research contributes to a global repository of information beneficial for the broader scientific community.

Dr. Daisuke Nakada's lab focuses on studying hematopoietic stem cells (HSCs), which are essential for producing all blood cell types in the body. The research explores how HSCs react to stress, particularly in conditions like anemia, and seeks to uncover mechanisms that can enhance blood regeneration. By using advanced techniques such as lineage tracing and gene expression analysis, the lab aims to improve understanding of HSC behavior, which could lead to innovative treatments for anemia and other blood disorders.

Dr. Yangjin Bae's lab at Baylor College of Medicine focuses on understanding and treating Osteogenesis Imperfecta (OI), a brittle bone disorder caused by genetic mutations affecting collagen. The lab researches how targeting a signaling protein called TGF can improve bone health in OI patients, especially those who do not respond well to existing therapies. Their work aims to develop new and effective treatments that can enhance bone density and healing for people with varying severities of OI.

Dr. Dongsu Park's lab at Baylor College of Medicine studies a genetic bone disorder called Osteogenesis Imperfecta (OI), which affects how bones grow and heal. They focus on understanding how changes in a specific type of stem cell, responsible for bone regeneration, are influenced by defects in collagen. The goal is to uncover new insights that could improve treatments for patients with OI, leading to better healing and bone strength.

Dr. Nicholas Tran's lab at Baylor College of Medicine focuses on understanding how different types of retinal ganglion cells respond to injury and treatments aimed at promoting healing and recovery. They conduct research exploring the links between cellular activity, cell type resilience, and the potential for axon regeneration following damage. The ultimate goal is to enhance therapies for conditions like glaucoma that lead to vision loss.

Dr. Fritz J. Sedlazeck's lab at Baylor College of Medicine focuses on improving the understanding of complex regions in the human genome, particularly those that impact cardiovascular disease risk. The lab develops innovative graph genome methods to analyze medically relevant genes, which will help identify genetic variants associated with diseases. Their work utilizes extensive genomic data and aims to make genetic analysis accessible to a broader community, ultimately contributing to better diagnostics and therapies for various conditions.

Dr. Pawel Stankiewicz's lab at Baylor College of Medicine focuses on understanding the genetic causes of severe lung disorders in newborns, specifically lethal lung developmental disorders like alveolar capillary dysplasia. The team investigates how specific genetic variants affect lung development and contribute to serious conditions like pulmonary arterial hypertension. Their ultimate goal is to improve diagnosis and treatment options for these disorders through a better understanding of genetic mechanisms.