Dr. Rodney J. Rothstein's lab focuses on understanding how cells repair DNA damage, specifically double-strand breaks that can occur during DNA replication or due to external factors. Using yeast as a model organism, the lab investigates the complex processes involved in genetic recombination and how these mechanisms can lead to genome stability, which is crucial for preventing diseases like cancer. Through innovative experimental designs, the lab aims to shed light on the timing and roles of various proteins in the DNA repair process.

Professor Alberto Ciccia's lab at Columbia University focuses on understanding how certain DNA repair mechanisms can influence cancer immunotherapy. By studying the role of the DNA translocase SMARCAL1, the lab aims to uncover how tumors evade the immune system and improve the effectiveness of treatments that rely on anti-tumor immune responses. Their research combines genetics, biochemistry, and animal models to explore the intricate relationships between DNA damage response and immune signaling.

Dr. Emmanuelle Passegue's lab at Columbia University focuses on understanding how blood cells develop and how their production can go awry in diseases like leukemia and during aging. The research involves investigating how special blood-forming cells adapt to challenges and stressors, which can lead to various blood disorders. By studying these processes, the lab aims to uncover new strategies for improving treatments for blood-related diseases.

Dr. Kristin Kay Baldwin’s research focuses on understanding how inhibitory interneurons, a crucial type of brain cell, develop and function. These neurons play a key role in regulating brain activity and are linked to various neurological disorders like autism and schizophrenia. Her lab aims to discover the genetic programs that allow these neurons to specialize and connect within brain circuits, ultimately leading to new therapies for brain diseases.

Dr. Gerard Karsenty's lab at Columbia University studies the relationship between bone health and aging. The research explores how bones not only decline with age but also play an active role in regulating various bodily functions. By understanding these connections, the lab aims to uncover new ways to combat age-related bone loss and improve overall health during aging.

Gary Struhl's lab at Columbia University focuses on understanding how signaling molecules, known as morphogens, control the growth and patterning of organs during development using the fruit fly Drosophila as a model organism. The research explores the complex interactions between these morphogens, their receptors, and the genetic elements they regulate, aiming to uncover insights that could inform therapeutic strategies for various human diseases, particularly developmental disorders and cancers.

Dr. Gennarino's lab focuses on understanding the role of the PUM1 gene in different neurological disorders. They study how various mutations in this gene lead to distinct symptoms, such as mild ataxia or severe developmental disorders. By creating mouse models and examining human cases, the lab aims to uncover the underlying molecular mechanisms that lead to these diverse phenotypes.

Dr. Amin Ghabrial's lab studies how tubes form in living organisms, particularly in fruit flies (Drosophila). The lab focuses on understanding the genetic and molecular mechanisms that control the shape and growth of these tubes, which are crucial for the functioning of various organs. By exploring these processes, the lab aims to uncover insights that could help in treating diseases in the lungs, vascular systems, and kidneys.