Dr. Lisa Miorin's lab focuses on understanding how specific genetic mutations affect the body's ability to fight off infections, particularly influenza. By studying a protein called ANKEF1 that helps move cilia in airway cells, the lab investigates how mutations can lead to severe complications like pneumonia and encephalitis. The research utilizes advanced technologies to explore the relationships between ciliary function, viral infections, and immune responses to identify potential new therapies for severe respiratory diseases.

Domenico Tortorella's lab at the Icahn School of Medicine focuses on developing new antiviral treatments for human cytomegalovirus (CMV), a common virus that can cause severe illness in newborns and immunocompromised patients. The research aims to identify and create compounds that can inhibit the early stages of CMV infection, potentially preventing its spread and reducing the associated health risks for vulnerable populations. This work is crucial as existing treatments often lead to drug resistance and severe side effects.

Dr. Christopher F. Basler's lab at the Icahn School of Medicine investigates how the Ebola virus assembles and infects cells, focusing on a key protein called VP24. This protein not only helps package viral components but also interferes with the body's immune response. By understanding VP24's functions, the lab aims to uncover new strategies for preventing and treating Ebola infections.

Dr. Matthew J. Evans' lab at the Icahn School of Medicine focuses on understanding how certain viruses, particularly flaviviruses like Zika and dengue, evade the human immune system. By studying the nonstructural protein 5 (NS5) of these viruses, the lab aims to reveal mechanisms of viral replication and immune suppression. This knowledge is crucial for developing new antiviral treatments and vaccines.

Dr. Lubbertus C. Mulder's lab focuses on understanding how drug use affects HIV latency, particularly in the brain's immune cells called microglia. The team is investigating a group of viruses known as human endogenous retroviruses (HERVs) and how they interact with HIV. Their goal is to find new markers for HIV latency and to see how these relationships can be influenced by narcotic use.

Dr. Viviana A Simon's research lab focuses on understanding HIV and coronavirus infections, particularly why some people can carry these viruses for long periods without clearing them. The lab employs advanced techniques to investigate how different immune cells interact with viruses like HIV and SARS-CoV-2. Additionally, they are working on developing vaccines that can provide broad protection against various coronaviruses. This lab combines clinical studies with cutting-edge molecular biology to uncover key insights that could lead to effective treatments and vaccines.

Dr. Rachel L Miller's lab focuses on understanding how prenatal and early life environmental exposures affect children's health, particularly concerning asthma and ADHD. The lab's research examines various physical, chemical, and social exposures that may contribute to these conditions, aiming to identify ways to improve prevention, treatment, and intervention strategies for affected children. By utilizing a large population cohort, the lab aims to generate impactful insights that will enhance clinical practices in pediatric health.

Dr. Goran Bajic's research lab focuses on understanding how our immune system responds to vaccines and infections, especially in the context of evolving viruses like SARS-CoV-2. The lab utilizes advanced techniques to study B cells, which play a crucial role in producing antibodies. By analyzing how these immune responses develop at a molecular level, the lab aims to improve vaccine design and enhance our capacity to fight rapidly changing pathogens, including various coronaviruses.

Dr. Adolfo Garcia-Sastre's lab at the Icahn School of Medicine focuses on studying how viruses, particularly SARS-CoV-2 and other coronaviruses, adapt to human hosts. By utilizing systems biology approaches and advanced modeling techniques, the lab aims to uncover biological networks that influence viral replication and disease severity. Their research seeks to identify potential biomarkers and therapeutic targets that can help in predicting disease outcomes and developing new treatments.

Dr. Jeffrey R. Johnson's lab focuses on understanding how viruses like HIV-1 and SARS-CoV-2 manipulate human cells during infection. The research aims to uncover the mechanisms by which these viruses degrade host proteins to enhance their replication and to identify potential therapeutic targets for treating viral infections. Through various molecular and genetic techniques, the lab strives to advance our understanding of viral biology and contribute to the development of new antiviral therapies.

Dr. Ana Fernandez-Sesma's lab focuses on understanding the human immune response to various viral infections and vaccinations, specifically SARS-CoV-2, seasonal influenza, and dengue viruses. The lab conducts comprehensive studies using advanced techniques to analyze immune system responses before and after vaccination, utilizing data from different human cohorts. By leveraging cutting-edge genomics and immunological profiling methods, the lab aims to generate valuable insights into vaccine effectiveness and immune memory.

Dr. Benhur Lee's lab is focused on researching henipaviruses and pararubulaviruses, which are serious threats to public health due to their high fatality rates and potential for causing pandemics. The lab develops antibodies that can neutralize these viruses and studies how they infect human cells. The goal is to provide effective treatments and preventive strategies against these dangerous viruses, enhancing global health security.