Dr. Jason D. Shepherd's lab at the University of Utah studies how brain cells communicate and change at the synapse—the connections between neurons—specifically focusing on the protein Arc, which plays a crucial role in learning and memory. The lab investigates how Arc forms virus-like structures that can carry genetic messages from one neuron to another, potentially impacting synaptic strength and memory formation. By understanding this process, the research aims to uncover new insights into the cognitive functions of the brain and the underlying mechanisms of various mental disorders.

Dr. Christopher Gregg's lab studies how genetic factors influence decision-making and behaviors, particularly in relation to mental health. They focus on genomic imprinting, which means that certain genes can be expressed depending on whether they come from the mother or the father. Using innovative techniques, they investigate how these genetic influences affect natural behaviors in mice, which may lead to new insights into human mental health and therapeutic approaches.

Dr. Emily Larsen Dennis's research lab focuses on improving the understanding and treatment of traumatic brain injuries (TBI) in children and adolescents. They are developing a comprehensive toolbox that addresses current limitations in neuroimaging analysis for pediatric populations, specifically tailored to the unique challenges presented by younger patients. This innovative approach aims to establish personalized profiles of pathology to better identify factors related to recovery and long-term outcomes for TBI patients.

Dr. Andres Villu Maricq's lab studies a specific type of brain receptor called NMDA receptors, which are crucial for learning and memory. By investigating how these receptors are regulated by a newly discovered protein, NRAP-1, they aim to better understand synaptic signaling in the nervous system. This research has important implications for treating conditions like schizophrenia and depression, as well as understanding fundamental brain processes.

Dr. Kevin Christopher Brennan's lab focuses on understanding migraines, a debilitating condition that affects millions globally. The research investigates the mechanisms behind migraine attacks, particularly how sensory phenomena like auras may indicate the progression of migraines. By combining imaging techniques and physiological assessments, the lab aims to identify biomarkers that predict migraine severity and progression, ultimately helping to develop better treatments and preventative strategies.

Dr. Stacey Lynn Clardy's lab focuses on treating and understanding N-methyl-D-aspartate receptor (NMDAR) encephalitis, a serious autoimmune brain disorder that can cause severe psychiatric and neurological problems. The lab is conducting clinical trials to evaluate a promising treatment using inebilizumab, a monoclonal antibody that targets specific immune cells. Their research aims not only to improve patient outcomes but also to identify predictive biomarkers for treatment responses.

Dr. Nichole L Link's lab focuses on understanding how certain RNA-binding proteins influence brain development and are connected to neurodevelopmental disorders like autism. They investigate the role of these proteins in stabilizing important mRNA molecules in neurons, which is crucial for proper brain formation. The lab uses advanced genetic models, including fruit flies and mouse cultures, to study these mechanisms and their implications for human diseases.

Dr. Oleksandr Shcheglovitov's lab focuses on creating and studying human brain organoids that mimic the connections in the cortico-striatal network, which is affected in various brain disorders such as Parkinson's disease and autism. The lab aims to develop a reliable method for generating these organoids from stem cells to investigate how these neural networks mature and function, as well as the cellular mechanisms at play. This research may lead to new insights and therapies for brain disorders impacting connectivity.

Dr. Moriel Zelikowsky's lab focuses on understanding how social isolation impacts aggression through brain mechanisms. By studying the medial prefrontal cortex and specific neuron types, the lab aims to uncover how these brain circuits can lead to increased aggression and insight into potential treatments for related mental health issues. This research is particularly relevant in light of growing societal concerns about aggression and violence driven by social isolation.

Dr. Daniel R. Scoles' lab focuses on understanding how certain kinases, particularly PASK, regulate cell processes and contribute to neurodegenerative diseases like ALS and FTD. They investigate the roles of protein modifications and genetic interactions, aiming to develop new therapeutic strategies. The research combines genetic models and cell studies to pave the way for potential treatments.

Dr. Monica Vetter's lab focuses on understanding how specific genes regulate the development of retinal cells in the eye. They study the role of a transcription factor called Foxp1 in guiding the differentiation of progenitor cells into various types of retinal neurons, such as ganglion and cone cells. This research aims to uncover potential methods to restore vision by regenerating lost retinal cell types due to disease or injury.