Anne E. Kwitek's lab focuses on the Rat Genome Database, which is a comprehensive resource for genomic data connected to rat models of human diseases. The lab aims to integrate various types of genetic and biological data to enhance understanding of complex diseases that affect humans. By collaborating with other labs and institutions, they work on developing new genomic resources and tools to facilitate research that can bridge the knowledge gaps between rat studies and human health.

Dr. Chun Liu's lab focuses on understanding how chemotherapy drugs, particularly anthracyclines like doxorubicin, can harm the heart of cancer survivors. They study a protein called Carbonic Anhydrase XII and its role in heart disease caused by these drugs. By using advanced cell models and genetic techniques, their research aims to uncover new ways to protect the heart, potentially leading to safer cancer treatments.

Dr. Ziqing Liu's lab focuses on understanding how certain proteins regulate blood vessel health. They study how endothelial cells, which form the inner lining of blood vessels, maintain their normal function and prevent inflammation, especially in conditions related to aging and cardiovascular diseases. By investigating the role of RNA-binding proteins, particularly PABPC1, they aim to uncover mechanisms that could lead to new strategies for preventing vascular-related health issues.

Caitlin O'Meara's lab focuses on understanding how heart cells, known as cardiomyocytes, can regenerate and repair after injury. By studying specific proteins in both zebrafish and mice, the lab aims to uncover mechanisms that allow heart cells to heal and function properly, especially in cases of heart failure. This research could lead to new regenerative therapies for patients with heart conditions.

Dr. Allen W. Cowley's lab investigates how a high-salt diet influences kidney health and metabolic processes, especially in individuals who are sensitive to salt. They focus on understanding the differences between salt-sensitive and salt-resistant rat models to identify potential therapeutic targets for hypertension and kidney injury. This research is significant given the widespread prevalence of salt-sensitive hypertension and its implications for cardiovascular health.

Dr. Justin Grobe's lab explores how specific neurons in the brain regulate blood pressure and metabolism, particularly how these functions change when someone becomes obese. The research focuses on the role of angiotensin receptors in neurons that respond to hunger signals and how their signaling pathways are altered during obesity. By understanding these changes, the lab aims to find new insights that could help manage obesity and hypertension in the population.

Dr. Aaron David Mickle's lab explores how bladder cells, called urothelial cells, communicate with nerve cells to contribute to sensations like pain and fullness in the bladder. By creating new models, they aim to understand how these cells and their signaling pathways may lead to conditions like overactive bladder and bladder pain syndrome. Their work could help develop better treatments for these common and painful bladder disorders.